TY - JOUR
T1 - Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
AU - Zamora-Ros, Raul
AU - Ferrari, Pietro
AU - Gonzalez, Carlos A.
AU - Tjonneland, Anne
AU - Olsen, Anja
AU - Bredsdorff, Lea
AU - Overvad, Kim
AU - Touillaud, Marina
AU - Perquier, Florence
AU - Fagherazzi, Guy
AU - Lukanova, Annekatrin
AU - Tikk, Kaja
AU - Aleksandrova, Krasimira
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Dilis, Vardis
AU - Masala, Giovanna
AU - Sieri, Sabina
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Bueno-de-Mesquita, H. Bas
AU - Peeters, Petra H. M.
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Engeset, Dagrun
AU - Menendez, Virginia
AU - Travier, Noemie
AU - Molina-Montes, Esther
AU - Amiano, Pilar
AU - Chirlaque, Maria-Dolores
AU - Barricarte, Aurelio
AU - Wallström, Peter
AU - Sonestedt, Emily
AU - Sund, Malin
AU - Landberg, Rikard
AU - Khaw, Kay-Thee
AU - Wareham, Nicholas J.
AU - Travis, Ruth C.
AU - Scalbert, Augustin
AU - Ward, Heather A.
AU - Riboli, Elio
AU - Romieu, Isabelle
PY - 2013
Y1 - 2013
N2 - Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.
AB - Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.
KW - Flavonoids
KW - Lignans
KW - Breast cancer
KW - Hormone receptors
KW - EPIC
U2 - 10.1007/s10549-013-2483-4
DO - 10.1007/s10549-013-2483-4
M3 - Article
C2 - 23572295
SN - 1573-7217
VL - 139
SP - 163
EP - 176
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -