Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

M Obón-Santacana; R Kaaks; N Slimani; L Lujan-Barroso; H Freisling; P Ferrari; L Dossus; N Chabbert-Buffet; L Baglietto; R T Fortner; H Boeing; A Tjønneland; A Olsen; K Overvad; V Menéndez; E Molina-Montes; N Larrañaga; M-D Chirlaque; E Ardanaz; K-T Khaw; N Wareham; R C Travis; Y Lu; M A Merritt; A Trichopoulou; V Benetou; D Trichopoulos; C Saieva; S Sieri; R Tumino; C Sacerdote; R Galasso; H B Bueno-de-Mesquita; Elisabet Wirfält; Ulrika Ericson; A Idahl; N Ohlson; G Skeie; I T Gram; E Weiderpass; N C Onland-Moret; E Riboli; E J Duell

doi:10.1038/bjc.2014.328

Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

M Obón-Santacana, R Kaaks, N Slimani, L Lujan-Barroso, H Freisling, P Ferrari, L Dossus, N Chabbert-Buffet, L Baglietto, R T Fortner, H Boeing, A Tjønneland, A Olsen, K Overvad, V Menéndez, E Molina-Montes, N Larrañaga, M-D Chirlaque, E Ardanaz, K-T KhawN Wareham, R C Travis, Y Lu, M A Merritt, A Trichopoulou, V Benetou, D Trichopoulos, C Saieva, S Sieri, R Tumino, C Sacerdote, R Galasso, H B Bueno-de-Mesquita, Elisabet Wirfält, Ulrika Ericson, A Idahl, N Ohlson, G Skeie, I T Gram, E Weiderpass, N C Onland-Moret, E Riboli, E J Duell

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Abstract

Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.

Original language	English
Pages (from-to)	987-997
Number of pages	11
Journal	British Journal of Cancer
Volume	111
Issue number	5
DOIs	https://doi.org/10.1038/bjc.2014.328
Publication status	Published - 2014

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Cancer and Oncology

UN SDGs

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http://www.ncbi.nlm.nih.gov/pubmed/24937665?dopt=Abstract

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Obón-Santacana, M., Kaaks, R., Slimani, N., Lujan-Barroso, L., Freisling, H., Ferrari, P., Dossus, L., Chabbert-Buffet, N., Baglietto, L., Fortner, R. T., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Menéndez, V., Molina-Montes, E., Larrañaga, N., Chirlaque, M.-D., Ardanaz, E., ... Duell, E. J. (2014). Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer, 111(5), 987-997. https://doi.org/10.1038/bjc.2014.328

@article{93eb55a0383349da8c8ea896ba73b942,

title = "Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.",

abstract = "Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.",

author = "M Ob{\'o}n-Santacana and R Kaaks and N Slimani and L Lujan-Barroso and H Freisling and P Ferrari and L Dossus and N Chabbert-Buffet and L Baglietto and Fortner, {R T} and H Boeing and A Tj{\o}nneland and A Olsen and K Overvad and V Men{\'e}ndez and E Molina-Montes and N Larra{\~n}aga and M-D Chirlaque and E Ardanaz and K-T Khaw and N Wareham and Travis, {R C} and Y Lu and Merritt, {M A} and A Trichopoulou and V Benetou and D Trichopoulos and C Saieva and S Sieri and R Tumino and C Sacerdote and R Galasso and Bueno-de-Mesquita, {H B} and Elisabet Wirf{\"a}lt and Ulrika Ericson and A Idahl and N Ohlson and G Skeie and Gram, {I T} and E Weiderpass and Onland-Moret, {N C} and E Riboli and Duell, {E J}",

year = "2014",

doi = "10.1038/bjc.2014.328",

language = "English",

volume = "111",

pages = "987--997",

journal = "British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

number = "5",

}

Obón-Santacana, M, Kaaks, R, Slimani, N, Lujan-Barroso, L, Freisling, H, Ferrari, P, Dossus, L, Chabbert-Buffet, N, Baglietto, L, Fortner, RT, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Menéndez, V, Molina-Montes, E, Larrañaga, N, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N, Travis, RC, Lu, Y, Merritt, MA, Trichopoulou, A, Benetou, V, Trichopoulos, D, Saieva, C, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Bueno-de-Mesquita, HB, Wirfält, E , Ericson, U, Idahl, A, Ohlson, N, Skeie, G, Gram, IT, Weiderpass, E, Onland-Moret, NC, Riboli, E & Duell, EJ 2014, 'Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.', British Journal of Cancer, vol. 111, no. 5, pp. 987-997. https://doi.org/10.1038/bjc.2014.328

TY - JOUR

T1 - Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

AU - Obón-Santacana, M

AU - Kaaks, R

AU - Slimani, N

AU - Lujan-Barroso, L

AU - Freisling, H

AU - Ferrari, P

AU - Dossus, L

AU - Chabbert-Buffet, N

AU - Baglietto, L

AU - Fortner, R T

AU - Boeing, H

AU - Tjønneland, A

AU - Olsen, A

AU - Overvad, K

AU - Menéndez, V

AU - Molina-Montes, E

AU - Larrañaga, N

AU - Chirlaque, M-D

AU - Ardanaz, E

AU - Khaw, K-T

AU - Wareham, N

AU - Travis, R C

AU - Lu, Y

AU - Merritt, M A

AU - Trichopoulou, A

AU - Benetou, V

AU - Trichopoulos, D

AU - Saieva, C

AU - Sieri, S

AU - Tumino, R

AU - Sacerdote, C

AU - Galasso, R

AU - Bueno-de-Mesquita, H B

AU - Wirfält, Elisabet

AU - Ericson, Ulrika

AU - Idahl, A

AU - Ohlson, N

AU - Skeie, G

AU - Gram, I T

AU - Weiderpass, E

AU - Onland-Moret, N C

AU - Riboli, E

AU - Duell, E J

PY - 2014

Y1 - 2014

N2 - Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.

AB - Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.

U2 - 10.1038/bjc.2014.328

DO - 10.1038/bjc.2014.328

M3 - Article

C2 - 24937665

SN - 1532-1827

VL - 111

SP - 987

EP - 997

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -

Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

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