Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Mauro Serafini; Paula Jakszyn; Leila Lujan-Barroso; Antonio Agudo; H. Bas Bueno-de-Mesquita; Franzel J. B. van Duijnhoven; Mazda Jenab; Carmen Navarro; Domenico Palli; Heiner Boeing; Peter Wallström; Sara Regnér; Mattijs E. Numans; Fatima Carneiro; Marie-Christine Boutron-Ruault; Francoise Clavel-Chapelon; Sophie Morois; Sara Grioni; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; Jose Ramon Quiros; Esther Molina-Montes; Jose M. Huerta Castano; Aurelio Barricarte; Pilar Amiano; Kay-Tee Khaw; Nicholas Wareham; Naomi E. Allen; Timothy J. Key; Suzanne M. Jeurnink; Petra H. M. Peeters; Christina Bamia; Elisabeth Valanou; Antonia Trichopoulou; Rudolf Kaaks; Annekatrin Lukanova; Manuela M. Bergmann; Bjorn Lindkvist; Roger Stenling; Ingegerd Johansson; Christina C. Dahm; Kim Overvad; Majken Jensen; Anja Olsen; Anne Tjonneland; Eiliv Lund; Sabina Rinaldi; Dominique Michaud; Traci Mouw; Elio Riboli; Carlos A. Gonzalez

doi:10.1002/ijc.27347

Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Mauro Serafini, Paula Jakszyn, Leila Lujan-Barroso, Antonio Agudo, H. Bas Bueno-de-Mesquita, Franzel J. B. van Duijnhoven, Mazda Jenab, Carmen Navarro, Domenico Palli, Heiner Boeing, Peter Wallström, Sara Regnér, Mattijs E. Numans, Fatima Carneiro, Marie-Christine Boutron-Ruault, Francoise Clavel-Chapelon, Sophie Morois, Sara Grioni, Salvatore Panico, Rosario TuminoCarlotta Sacerdote, Jose Ramon Quiros, Esther Molina-Montes, Jose M. Huerta Castano, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Nicholas Wareham, Naomi E. Allen, Timothy J. Key, Suzanne M. Jeurnink, Petra H. M. Peeters, Christina Bamia, Elisabeth Valanou, Antonia Trichopoulou, Rudolf Kaaks, Annekatrin Lukanova, Manuela M. Bergmann, Bjorn Lindkvist, Roger Stenling, Ingegerd Johansson, Christina C. Dahm, Kim Overvad, Majken Jensen, Anja Olsen, Anne Tjonneland, Eiliv Lund, Sabina Rinaldi, Dominique Michaud, Traci Mouw, Elio Riboli, Carlos A. Gonzalez

Research output: Contribution to journal › Article › peer-review

Abstract

A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

Original language	English
Pages (from-to)	E544-E554
Journal	International Journal of Cancer
Volume	131
Issue number	4
DOIs	https://doi.org/10.1002/ijc.27347
Publication status	Published - 2012

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

longitudinal studies
antioxidant capacity
diet
stomach cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.27347

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Serafini, M., Jakszyn, P., Lujan-Barroso, L., Agudo, A., Bueno-de-Mesquita, H. B., van Duijnhoven, F. J. B., Jenab, M., Navarro, C., Palli, D., Boeing, H., Wallström, P., Regnér, S., Numans, M. E., Carneiro, F., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Morois, S., Grioni, S., Panico, S., ... Gonzalez, C. A. (2012). Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 131(4), E544-E554. https://doi.org/10.1002/ijc.27347

@article{2215bdb9bc2d4a1090a13c213e14871e,

title = "Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study",

abstract = "A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.",

keywords = "longitudinal studies, antioxidant capacity, diet, stomach cancer",

author = "Mauro Serafini and Paula Jakszyn and Leila Lujan-Barroso and Antonio Agudo and Bueno-de-Mesquita, {H. Bas} and {van Duijnhoven}, {Franzel J. B.} and Mazda Jenab and Carmen Navarro and Domenico Palli and Heiner Boeing and Peter Wallstr{\"o}m and Sara Regn{\'e}r and Numans, {Mattijs E.} and Fatima Carneiro and Marie-Christine Boutron-Ruault and Francoise Clavel-Chapelon and Sophie Morois and Sara Grioni and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and {Ramon Quiros}, Jose and Esther Molina-Montes and {Huerta Castano}, {Jose M.} and Aurelio Barricarte and Pilar Amiano and Kay-Tee Khaw and Nicholas Wareham and Allen, {Naomi E.} and Key, {Timothy J.} and Jeurnink, {Suzanne M.} and Peeters, {Petra H. M.} and Christina Bamia and Elisabeth Valanou and Antonia Trichopoulou and Rudolf Kaaks and Annekatrin Lukanova and Bergmann, {Manuela M.} and Bjorn Lindkvist and Roger Stenling and Ingegerd Johansson and Dahm, {Christina C.} and Kim Overvad and Majken Jensen and Anja Olsen and Anne Tjonneland and Eiliv Lund and Sabina Rinaldi and Dominique Michaud and Traci Mouw and Elio Riboli and Gonzalez, {Carlos A.}",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)",

year = "2012",

doi = "10.1002/ijc.27347",

language = "English",

volume = "131",

pages = "E544--E554",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Inc.",

number = "4",

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Serafini, M, Jakszyn, P, Lujan-Barroso, L, Agudo, A, Bueno-de-Mesquita, HB, van Duijnhoven, FJB, Jenab, M, Navarro, C, Palli, D, Boeing, H, Wallström, P , Regnér, S, Numans, ME, Carneiro, F, Boutron-Ruault, M-C, Clavel-Chapelon, F, Morois, S, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, Ramon Quiros, J, Molina-Montes, E, Huerta Castano, JM, Barricarte, A, Amiano, P, Khaw, K-T, Wareham, N, Allen, NE, Key, TJ, Jeurnink, SM, Peeters, PHM, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, MM, Lindkvist, B, Stenling, R, Johansson, I, Dahm, CC, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Lund, E, Rinaldi, S, Michaud, D, Mouw, T, Riboli, E & Gonzalez, CA 2012, 'Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study', International Journal of Cancer, vol. 131, no. 4, pp. E544-E554. https://doi.org/10.1002/ijc.27347

TY - JOUR

T1 - Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

AU - Serafini, Mauro

AU - Jakszyn, Paula

AU - Lujan-Barroso, Leila

AU - Agudo, Antonio

AU - Bueno-de-Mesquita, H. Bas

AU - van Duijnhoven, Franzel J. B.

AU - Jenab, Mazda

AU - Navarro, Carmen

AU - Palli, Domenico

AU - Boeing, Heiner

AU - Wallström, Peter

AU - Regnér, Sara

AU - Numans, Mattijs E.

AU - Carneiro, Fatima

AU - Boutron-Ruault, Marie-Christine

AU - Clavel-Chapelon, Francoise

AU - Morois, Sophie

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Ramon Quiros, Jose

AU - Molina-Montes, Esther

AU - Huerta Castano, Jose M.

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E.

AU - Key, Timothy J.

AU - Jeurnink, Suzanne M.

AU - Peeters, Petra H. M.

AU - Bamia, Christina

AU - Valanou, Elisabeth

AU - Trichopoulou, Antonia

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Bergmann, Manuela M.

AU - Lindkvist, Bjorn

AU - Stenling, Roger

AU - Johansson, Ingegerd

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Jensen, Majken

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Lund, Eiliv

AU - Rinaldi, Sabina

AU - Michaud, Dominique

AU - Mouw, Traci

AU - Riboli, Elio

AU - Gonzalez, Carlos A.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)

PY - 2012

Y1 - 2012

N2 - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

AB - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.

KW - longitudinal studies

KW - antioxidant capacity

KW - diet

KW - stomach cancer

U2 - 10.1002/ijc.27347

DO - 10.1002/ijc.27347

M3 - Article

SN - 0020-7136

VL - 131

SP - E544-E554

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

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