Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries.

Lars Edvinsson, Hilda Ahnstedt, R Larsen, M Sheykhzade

Research output: Contribution to journalArticlepeer-review

18 Citations (SciVal)

Abstract

Calcitonin gene-related peptide (CGRP) and its receptor are widely distributed within the circulation and the mechanism behind its vasodilation not only differs from one animal species to another but is also dependent on the type and size of vessel. The present study examines the nature of CGRP-induced vasodilation, characteristics of the CGRP receptor antagonist telcagepant and localization of the key components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) of the CGRP receptor in human subcutaneous arteries.
Original languageEnglish
Pages (from-to)811-822
JournalActa Physiologica
Volume210
Issue number4
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Physiology

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