Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

K. J. M. Brolin; Kristina Persson; M. Wahlgren; S. J. Rogerson; Q. J. Chen

doi:10.1371/journal.pone.0009230

Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

K. J. M. Brolin, Kristina Persson, M. Wahlgren, S. J. Rogerson, Q. J. Chen

Karolinska Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.

Original language	English
Article number	e9230
Journal	PLoS ONE
Volume	5
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0009230
Publication status	Published - 2010
Externally published	Yes

Bibliographical note

2

Subject classification (UKÄ)

Immunology in the Medical Area (including Cell and Immunotherapy)

Free keywords

chondroitin sulfate-a
variant surface-antigens
sub-saharan africa
plasmodium-falciparum
infected erythrocytes
structural basis
binding
placenta
adhesion
receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0009230

Cite this

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title = "Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area",

abstract = "Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.",

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AU - Brolin, K. J. M.

AU - Persson, Kristina

AU - Wahlgren, M.

AU - Rogerson, S. J.

AU - Chen, Q. J.

N1 - 2

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Y1 - 2010

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AB - Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.

KW - chondroitin sulfate-a

KW - variant surface-antigens

KW - sub-saharan africa

KW - plasmodium-falciparum

KW - infected erythrocytes

KW - structural basis

KW - binding

KW - placenta

KW - adhesion

KW - receptor

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DO - 10.1371/journal.pone.0009230

M3 - Article

SN - 1932-6203

VL - 5

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - e9230

ER -

Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

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