Differentiation of diabetes by pathophysiology, natural history, and prognosis

Jay S Skyler; George L. Bakris; Ezio Bonifacio; Tamara Darsow; Robert H. Eckel; Leif Groop; Per-Henrik Groop; Yehuda Handelsman; Richard A Insel; Chantal Mathieu; Allison T. McElvaine; Jerry P. Palmer; Alberto Pugliese; Desmond A Schatz; Jay M Sosenko; John P H Wilding; Robert E Ratner

doi:10.2337/db16-0806

Differentiation of diabetes by pathophysiology, natural history, and prognosis

Jay S Skyler, George L. Bakris, Ezio Bonifacio, Tamara Darsow, Robert H. Eckel, Leif Groop, Per-Henrik Groop, Yehuda Handelsman, Richard A Insel, Chantal Mathieu, Allison T. McElvaine, Jerry P. Palmer, Alberto Pugliese, Desmond A Schatz, Jay M Sosenko, John P H Wilding, Robert E Ratner

Research output: Contribution to journal › Review article › peer-review

Abstract

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

Original language	English
Pages (from-to)	241-255
Number of pages	15
Journal	Diabetes
Volume	66
Issue number	2
DOIs	https://doi.org/10.2337/db16-0806
Publication status	Published - 2017 Feb 1

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/db16-0806

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Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P.-H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H., & Ratner, R. E. (2017). Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes, 66(2), 241-255. https://doi.org/10.2337/db16-0806

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title = "Differentiation of diabetes by pathophysiology, natural history, and prognosis",

abstract = "The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, {"}The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis{"} on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.",

author = "Skyler, {Jay S} and Bakris, {George L.} and Ezio Bonifacio and Tamara Darsow and Eckel, {Robert H.} and Leif Groop and Per-Henrik Groop and Yehuda Handelsman and Insel, {Richard A} and Chantal Mathieu and McElvaine, {Allison T.} and Palmer, {Jerry P.} and Alberto Pugliese and Schatz, {Desmond A} and Sosenko, {Jay M} and Wilding, {John P H} and Ratner, {Robert E}",

year = "2017",

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doi = "10.2337/db16-0806",

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Skyler, JS, Bakris, GL, Bonifacio, E, Darsow, T, Eckel, RH, Groop, L, Groop, P-H, Handelsman, Y, Insel, RA, Mathieu, C, McElvaine, AT, Palmer, JP, Pugliese, A, Schatz, DA, Sosenko, JM, Wilding, JPH & Ratner, RE 2017, 'Differentiation of diabetes by pathophysiology, natural history, and prognosis', Diabetes, vol. 66, no. 2, pp. 241-255. https://doi.org/10.2337/db16-0806

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T1 - Differentiation of diabetes by pathophysiology, natural history, and prognosis

AU - Skyler, Jay S

AU - Bakris, George L.

AU - Bonifacio, Ezio

AU - Darsow, Tamara

AU - Eckel, Robert H.

AU - Groop, Leif

AU - Groop, Per-Henrik

AU - Handelsman, Yehuda

AU - Insel, Richard A

AU - Mathieu, Chantal

AU - McElvaine, Allison T.

AU - Palmer, Jerry P.

AU - Pugliese, Alberto

AU - Schatz, Desmond A

AU - Sosenko, Jay M

AU - Wilding, John P H

AU - Ratner, Robert E

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

AB - The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

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DO - 10.2337/db16-0806

M3 - Review article

C2 - 27980006

AN - SCOPUS:85011634413

SN - 0012-1797

VL - 66

SP - 241

EP - 255

JO - Diabetes

JF - Diabetes

IS - 2

ER -

Differentiation of diabetes by pathophysiology, natural history, and prognosis

Abstract

Subject classification (UKÄ)

UN SDGs

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