Direct and endothelium-linked serotonergic control of vascular tone in human uterine and umbilical arteries

Caroline Karlsson

Research output: ThesisDoctoral Thesis (compilation)

Abstract

The serotonergic vascular control was investigated by in vitro pharmacology in the human uterine and umbilical arteries. The localisation of immunoreactive (IR) neuropeptide Y (NPY) and the influence of NPY on the adrenergic vascular effects in the human uterine artery were also studied. NPY-IR nerve fibres were observed predominantly at the media-adventitial border of the uterine artery. About 50% of the NPY-IR nerve fibres also contained tyrosine hydroxylase-IR. NPY potentiated the noradrenergic contraction in the uterine artery but had no effect per se. The receptors mediating the serotonergic contractile effect in the human uterine artery were of the 5-hydroxytryptamine (5-HT)2-subtype with a minor contribution of 5-HT1 receptors. The endothelium of the uterine artery secreted a vasodilating substance in response to 5-HT. This substance seemed to be a prostanoid, probably prostacylin. The endothelium-linked effect appeared to be mediated by 5-HT1 receptors. In the human umbilical artery 5-HT mediated a contraction via a mixed population of 5-HT1 and 5-HT2 receptors. The endothelium secreted a vasoconstrictive substance in response to 5-HT. This endothelium-linked effect also appeared to be mediated by receptors of the 5-HT1 subtype. It was not possible to detect the substance released by the endothelium of the umbilical artery in response to 5-HT, although endothelin could not be excluded.
Original languageEnglish
QualificationDoctor
Awarding Institution
  • Obstetric, Gynaecological and Prenatal Ultrasound Research
Supervisors/Advisors
  • [unknown], [unknown], Supervisor, External person
Award date1998 Jun 12
Publisher
Publication statusPublished - 1998

Bibliographical note

Defence details

Date: 1998-06-12
Time: 09:15
Place: Lecture Hall, Department of Obstetrics & Gynaecology, University Hospital MAS, S-205 02 Malmö, Sweden

External reviewer(s)

Name: Nisell, Henry
Title: Associate Professor
Affiliation: Huddinge

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Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine

Keywords

  • andrology
  • gynaecology
  • Obstetrics
  • vascular smooth muscle
  • uterine artery (human)
  • umbilical artery (human)
  • serotonergic receptor
  • 5-HT
  • noradrenaline
  • endothelium
  • NPY
  • reproduction
  • sexuality
  • Obstetrik
  • gynekologi
  • andrologi
  • reproduktion
  • sexualitet

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