Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

Maria Kempe, Klaus Mosbach

Research output: Contribution to journalArticlepeer-review

Abstract

A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
Original languageEnglish
Pages (from-to)276-279
JournalJournal of Chromatography A
Volume664
Issue number2
DOIs
Publication statusPublished - 1994

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

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