Abstract
A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
Original language | English |
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Pages (from-to) | 276-279 |
Journal | Journal of Chromatography A |
Volume | 664 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1994 |
Subject classification (UKÄ)
- Biochemistry and Molecular Biology