Discovery and refinement of loci associated with lipid levels

Cristen J. Willer; Ellen M. Schmidt; Sebanti Sengupta; Gina M. Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg-Gresham; Hsing-Yi Chang; Ayse Demirkan; Heleen M. Den Hertog; Ron Do; Louise A. Donnelly; Georg B. Ehret; Tonu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkila; Elina Hyppoenen; Aaron Isaacs; Anne U. Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikainen; Patrik K. E. Magnusson; Massimo Mangino; Evelin Mihailov; May E. Montasser; Martina Mueller-Nurasyid; Ilja M. Nolte; Jeffrey R. O'Connell; Cameron D. Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den Herik; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Ines Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F. Doney; Angela Doering; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Groves; Goran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimaki; Shih-Yi Lin; Jaana Lindstrom; Ruth J. F. Loos; Francois Mach; Wendy L. McArdle; Christa Meisinger; Braxton D. Mitchell; Gabrielle Mueller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V. M. Nieminen; Rebecca N. Nsubuga; Isleifur Olafsson; Ken K. Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Daniel J. Rader; Muredach P. Reilly; Paul M. Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Nilesh Samani; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stancakova; Kathleen Stirrups; Amy J. Swift; Laurence Tiret; Andre G. Uitterlinden; L. Joost van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H. Wild; Gonneke Willemsen; Tom Wilsgaard; James F. Wilson; Elizabeth H. Young; Jing Hua Zhao; Linda S. Adair; Dominique Arveiler; Themistocles L. Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O. Boehm; Dorret I. Boomsma; Ingrid B. Borecki; Stefan R. Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C. Chambers; Yii-Der Ida Chen; Francis S. Collins; Richard S. Cooper; John Danesh; George Dedoussis; Ulf de Faire; Alan B. Feranil; Jean Ferrieres; Luigi Ferrucci; Nelson B. Freimer; Christian Gieger; Leif Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Aroon Hingorani; Joel N. Hirschhorn; Albert Hofman; G. Kees Hovingh; Chao Agnes Hsiung; Steve E. Humphries; Steven C. Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Jarvelin; Antti Jula; Mika Kahonen; Jaakko Kaprio; Antero Kesaniemi; Mika Kivimaki; Jaspal S. Kooner; Peter J. Koudstaal; Ronald M. Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O. Kyvik; Markku Laakso; Timo A. Lakka; Lars Lind; Cecilia M. Lindgren; Nicholas G. Martin; Winfried Maerz; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D. Morris; Patricia B. Munroe; Inger Njolstad; Nancy L. Pedersen; Chris Power; Peter P. Pramstaller; Jackie F. Price; Bruce M. Psaty; Thomas Quertermous; Rainer Rauramaa; Danish Saleheen; Veikko Salomaa; Dharambir K. Sanghera; Jouko Saramies; Peter E. H. Schwarz; Wayne H-H Sheu; Alan R. Shuldiner; Agneta Siegbahn; Tim D. Spector; Kari Stefansson; David P. Strachan; Bamidele O. Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M. van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J. Wareham; John B. Whitfield; Bruce H. R. Wolffenbuttel; Jose M. Ordovas; Eric Boerwinkle; Colin N. A. Palmer; Unnur Thorsteinsdottir; Daniel I. Chasman; Jerome I. Rotter; Paul Franks; Samuli Ripatti; L. Adrienne Cupples; Manjinder S. Sandhu; Stephen S. Rich; Michael Boehnke; Panos Deloukas; Sekar Kathiresan; Karen L. Mohlke; Erik Ingelsson; Goncalo R. Abecasis

doi:10.1038/ng.2797

Discovery and refinement of loci associated with lipid levels

Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, Martin L. Buchkovich, Samia Mora, Jacques S. Beckmann, Jennifer L. Bragg-Gresham, Hsing-Yi Chang, Ayse Demirkan, Heleen M. Den Hertog, Ron Do, Louise A. Donnelly, Georg B. Ehret, Tonu Esko, Mary F. FeitosaTeresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani, Kauko Heikkila, Elina Hyppoenen, Aaron Isaacs, Anne U. Jackson, Asa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian'an Luan, Leo-Pekka Lyytikainen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Martina Mueller-Nurasyid, Ilja M. Nolte, Jeffrey R. O'Connell, Cameron D. Palmer, Markus Perola, Ann-Kristin Petersen, Serena Sanna, Richa Saxena, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore, Ci Song, Rona J. Strawbridge, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Gudmar Thorleifsson, Evita G. Van den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, Devin Absher, Gershim Asiki, Ines Barroso, Latonya F. Been, Jennifer L. Bolton, Lori L. Bonnycastle, Paolo Brambilla, Mary S. Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Doering, Paul Elliott, Stephen E. Epstein, Gudmundur Ingi Eyjolfsson, Bruna Gigante, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Goran Hallmans, Anna-Liisa Hartikainen, Caroline Hayward, Dena Hernandez, Andrew A. Hicks, Hilma Holm, Yi-Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J. P. Kastelein, Kay-Tee Khaw, Eric Kim, Norman Klopp, Pirjo Komulainen, Meena Kumari, Claudia Langenberg, Terho Lehtimaki, Shih-Yi Lin, Jaana Lindstrom, Ruth J. F. Loos, Francois Mach, Wendy L. McArdle, Christa Meisinger, Braxton D. Mitchell, Gabrielle Mueller, Ramaiah Nagaraja, Narisu Narisu, Tuomo V. M. Nieminen, Rebecca N. Nsubuga, Isleifur Olafsson, Ken K. Ong, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Daniel J. Rader, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, Aimo Ruokonen, Nilesh Samani, Hubert Scharnagl, Janet Seeley, Kaisa Silander, Alena Stancakova, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, Andre G. Uitterlinden, L. Joost van Pelt, Sailaja Vedantam, Nicholas Wainwright, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth H. Young, Jing Hua Zhao, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Richard S. Cooper, John Danesh, George Dedoussis, Ulf de Faire, Alan B. Feranil, Jean Ferrieres, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger, Leif Groop, Vilmundur Gudnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon Hingorani, Joel N. Hirschhorn, Albert Hofman, G. Kees Hovingh, Chao Agnes Hsiung, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Carlos Iribarren, Marjo-Riitta Jarvelin, Antti Jula, Mika Kahonen, Jaakko Kaprio, Antero Kesaniemi, Mika Kivimaki, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten O. Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin, Winfried Maerz, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njolstad, Nancy L. Pedersen, Chris Power, Peter P. Pramstaller, Jackie F. Price, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Danish Saleheen, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Wayne H-H Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kari Stefansson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, Cornelia M. van Duijn, Peter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, Jose M. Ordovas, Eric Boerwinkle, Colin N. A. Palmer, Unnur Thorsteinsdottir, Daniel I. Chasman, Jerome I. Rotter, Paul Franks, Samuli Ripatti, L. Adrienne Cupples, Manjinder S. Sandhu, Stephen S. Rich, Michael Boehnke, Panos Deloukas, Sekar Kathiresan, Karen L. Mohlke, Erik Ingelsson, Goncalo R. Abecasis

Research output: Contribution to journal › Article › peer-review

Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

Original language	English
Pages (from-to)	1274
Journal	Nature Genetics
Volume	45
Issue number	11
DOIs	https://doi.org/10.1038/ng.2797
Publication status	Published - 2013

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.2797

Cite this

Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., ... Abecasis, G. R. (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45(11), 1274. https://doi.org/10.1038/ng.2797

@article{4f07f785c86940bb91542164c325b5a9,

title = "Discovery and refinement of loci associated with lipid levels",

abstract = "Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.",

author = "Willer, {Cristen J.} and Schmidt, {Ellen M.} and Sebanti Sengupta and Peloso, {Gina M.} and Stefan Gustafsson and Stavroula Kanoni and Andrea Ganna and Jin Chen and Buchkovich, {Martin L.} and Samia Mora and Beckmann, {Jacques S.} and Bragg-Gresham, {Jennifer L.} and Hsing-Yi Chang and Ayse Demirkan and {Den Hertog}, {Heleen M.} and Ron Do and Donnelly, {Louise A.} and Ehret, {Georg B.} and Tonu Esko and Feitosa, {Mary F.} and Teresa Ferreira and Krista Fischer and Pierre Fontanillas and Fraser, {Ross M.} and Freitag, {Daniel F.} and Deepti Gurdasani and Kauko Heikkila and Elina Hyppoenen and Aaron Isaacs and Jackson, {Anne U.} and Asa Johansson and Toby Johnson and Marika Kaakinen and Johannes Kettunen and Kleber, {Marcus E.} and Xiaohui Li and Jian'an Luan and Leo-Pekka Lyytikainen and Magnusson, {Patrik K. E.} and Massimo Mangino and Evelin Mihailov and Montasser, {May E.} and Martina Mueller-Nurasyid and Nolte, {Ilja M.} and O'Connell, {Jeffrey R.} and Palmer, {Cameron D.} and Markus Perola and Ann-Kristin Petersen and Serena Sanna and Richa Saxena and Service, {Susan K.} and Sonia Shah and Dmitry Shungin and Carlo Sidore and Ci Song and Strawbridge, {Rona J.} and Ida Surakka and Toshiko Tanaka and Teslovich, {Tanya M.} and Gudmar Thorleifsson and {Van den Herik}, {Evita G.} and Voight, {Benjamin F.} and Volcik, {Kelly A.} and Waite, {Lindsay L.} and Andrew Wong and Ying Wu and Weihua Zhang and Devin Absher and Gershim Asiki and Ines Barroso and Been, {Latonya F.} and Bolton, {Jennifer L.} and Bonnycastle, {Lori L.} and Paolo Brambilla and Burnett, {Mary S.} and Giancarlo Cesana and Maria Dimitriou and Doney, {Alex S. F.} and Angela Doering and Paul Elliott and Epstein, {Stephen E.} and Eyjolfsson, {Gudmundur Ingi} and Bruna Gigante and Goodarzi, {Mark O.} and Harald Grallert and Gravito, {Martha L.} and Groves, {Christopher J.} and Goran Hallmans and Anna-Liisa Hartikainen and Caroline Hayward and Dena Hernandez and Hicks, {Andrew A.} and Hilma Holm and Yi-Jen Hung and Thomas Illig and Jones, {Michelle R.} and Pontiano Kaleebu and Kastelein, {John J. P.} and Kay-Tee Khaw and Eric Kim and Norman Klopp and Pirjo Komulainen and Meena Kumari and Claudia Langenberg and Terho Lehtimaki and Shih-Yi Lin and Jaana Lindstrom and Loos, {Ruth J. F.} and Francois Mach and McArdle, {Wendy L.} and Christa Meisinger and Mitchell, {Braxton D.} and Gabrielle Mueller and Ramaiah Nagaraja and Narisu Narisu and Nieminen, {Tuomo V. M.} and Nsubuga, {Rebecca N.} and Isleifur Olafsson and Ong, {Ken K.} and Aarno Palotie and Theodore Papamarkou and Cristina Pomilla and Anneli Pouta and Rader, {Daniel J.} and Reilly, {Muredach P.} and Ridker, {Paul M.} and Fernando Rivadeneira and Igor Rudan and Aimo Ruokonen and Nilesh Samani and Hubert Scharnagl and Janet Seeley and Kaisa Silander and Alena Stancakova and Kathleen Stirrups and Swift, {Amy J.} and Laurence Tiret and Uitterlinden, {Andre G.} and {van Pelt}, {L. Joost} and Sailaja Vedantam and Nicholas Wainwright and Cisca Wijmenga and Wild, {Sarah H.} and Gonneke Willemsen and Tom Wilsgaard and Wilson, {James F.} and Young, {Elizabeth H.} and Zhao, {Jing Hua} and Adair, {Linda S.} and Dominique Arveiler and Assimes, {Themistocles L.} and Stefania Bandinelli and Franklyn Bennett and Murielle Bochud and Boehm, {Bernhard O.} and Boomsma, {Dorret I.} and Borecki, {Ingrid B.} and Bornstein, {Stefan R.} and Pascal Bovet and Michel Burnier and Harry Campbell and Aravinda Chakravarti and Chambers, {John C.} and Chen, {Yii-Der Ida} and Collins, {Francis S.} and Cooper, {Richard S.} and John Danesh and George Dedoussis and {de Faire}, Ulf and Feranil, {Alan B.} and Jean Ferrieres and Luigi Ferrucci and Freimer, {Nelson B.} and Christian Gieger and Leif Groop and Vilmundur Gudnason and Ulf Gyllensten and Anders Hamsten and Harris, {Tamara B.} and Aroon Hingorani and Hirschhorn, {Joel N.} and Albert Hofman and Hovingh, {G. Kees} and Hsiung, {Chao Agnes} and Humphries, {Steve E.} and Hunt, {Steven C.} and Kristian Hveem and Carlos Iribarren and Marjo-Riitta Jarvelin and Antti Jula and Mika Kahonen and Jaakko Kaprio and Antero Kesaniemi and Mika Kivimaki and Kooner, {Jaspal S.} and Koudstaal, {Peter J.} and Krauss, {Ronald M.} and Diana Kuh and Johanna Kuusisto and Kyvik, {Kirsten O.} and Markku Laakso and Lakka, {Timo A.} and Lars Lind and Lindgren, {Cecilia M.} and Martin, {Nicholas G.} and Winfried Maerz and McCarthy, {Mark I.} and McKenzie, {Colin A.} and Pierre Meneton and Andres Metspalu and Leena Moilanen and Morris, {Andrew D.} and Munroe, {Patricia B.} and Inger Njolstad and Pedersen, {Nancy L.} and Chris Power and Pramstaller, {Peter P.} and Price, {Jackie F.} and Psaty, {Bruce M.} and Thomas Quertermous and Rainer Rauramaa and Danish Saleheen and Veikko Salomaa and Sanghera, {Dharambir K.} and Jouko Saramies and Schwarz, {Peter E. H.} and Sheu, {Wayne H-H} and Shuldiner, {Alan R.} and Agneta Siegbahn and Spector, {Tim D.} and Kari Stefansson and Strachan, {David P.} and Tayo, {Bamidele O.} and Elena Tremoli and Jaakko Tuomilehto and Matti Uusitupa and {van Duijn}, {Cornelia M.} and Peter Vollenweider and Lars Wallentin and Wareham, {Nicholas J.} and Whitfield, {John B.} and Wolffenbuttel, {Bruce H. R.} and Ordovas, {Jose M.} and Eric Boerwinkle and Palmer, {Colin N. A.} and Unnur Thorsteinsdottir and Chasman, {Daniel I.} and Rotter, {Jerome I.} and Paul Franks and Samuli Ripatti and Cupples, {L. Adrienne} and Sandhu, {Manjinder S.} and Rich, {Stephen S.} and Michael Boehnke and Panos Deloukas and Sekar Kathiresan and Mohlke, {Karen L.} and Erik Ingelsson and Abecasis, {Goncalo R.}",

year = "2013",

doi = "10.1038/ng.2797",

language = "English",

volume = "45",

pages = "1274",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

number = "11",

}

Willer, CJ, Schmidt, EM, Sengupta, S, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Den Hertog, HM, Do, R, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkila, K, Hyppoenen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J, Lyytikainen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Mueller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, Van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Doering, A, Elliott, P, Epstein, SE, Eyjolfsson, GI, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, Y-J, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimaki, T, Lin, S-Y, Lindstrom, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Mueller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stancakova, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, van Pelt, LJ, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JH, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, Y-DI, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrieres, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, L, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, Hovingh, GK, Hsiung, CA, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Jarvelin, M-R, Jula, A, Kahonen, M, Kaprio, J, Kesaniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, Maerz, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njolstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WH-H, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, P, Ripatti, S, Cupples, LA, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Kathiresan, S, Mohlke, KL, Ingelsson, E & Abecasis, GR 2013, 'Discovery and refinement of loci associated with lipid levels', Nature Genetics, vol. 45, no. 11, pp. 1274. https://doi.org/10.1038/ng.2797

TY - JOUR

T1 - Discovery and refinement of loci associated with lipid levels

AU - Willer, Cristen J.

AU - Schmidt, Ellen M.

AU - Sengupta, Sebanti

AU - Peloso, Gina M.

AU - Gustafsson, Stefan

AU - Kanoni, Stavroula

AU - Ganna, Andrea

AU - Chen, Jin

AU - Buchkovich, Martin L.

AU - Mora, Samia

AU - Beckmann, Jacques S.

AU - Bragg-Gresham, Jennifer L.

AU - Chang, Hsing-Yi

AU - Demirkan, Ayse

AU - Den Hertog, Heleen M.

AU - Do, Ron

AU - Donnelly, Louise A.

AU - Ehret, Georg B.

AU - Esko, Tonu

AU - Feitosa, Mary F.

AU - Ferreira, Teresa

AU - Fischer, Krista

AU - Fontanillas, Pierre

AU - Fraser, Ross M.

AU - Freitag, Daniel F.

AU - Gurdasani, Deepti

AU - Heikkila, Kauko

AU - Hyppoenen, Elina

AU - Isaacs, Aaron

AU - Jackson, Anne U.

AU - Johansson, Asa

AU - Johnson, Toby

AU - Kaakinen, Marika

AU - Kettunen, Johannes

AU - Kleber, Marcus E.

AU - Li, Xiaohui

AU - Luan, Jian'an

AU - Lyytikainen, Leo-Pekka

AU - Magnusson, Patrik K. E.

AU - Mangino, Massimo

AU - Mihailov, Evelin

AU - Montasser, May E.

AU - Mueller-Nurasyid, Martina

AU - Nolte, Ilja M.

AU - O'Connell, Jeffrey R.

AU - Palmer, Cameron D.

AU - Perola, Markus

AU - Petersen, Ann-Kristin

AU - Sanna, Serena

AU - Saxena, Richa

AU - Service, Susan K.

AU - Shah, Sonia

AU - Shungin, Dmitry

AU - Sidore, Carlo

AU - Song, Ci

AU - Strawbridge, Rona J.

AU - Surakka, Ida

AU - Tanaka, Toshiko

AU - Teslovich, Tanya M.

AU - Thorleifsson, Gudmar

AU - Van den Herik, Evita G.

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PY - 2013

Y1 - 2013

N2 - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

AB - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

U2 - 10.1038/ng.2797

DO - 10.1038/ng.2797

M3 - Article

C2 - 24097068

SN - 1546-1718

VL - 45

SP - 1274

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Discovery and refinement of loci associated with lipid levels

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