Disease models of chronic inflammatory airway disease: applications and requirements for clinical trials.

Zuzana Diamant, Graham W Clarke, Herman Pieterse, Juan Gispert

Research output: Contribution to journalReview articlepeer-review

1 Citation (SciVal)

Abstract

This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products used in bronchial challenges or clinical inflammatory models of respiratory disease will be highlighted.
Original languageEnglish
Pages (from-to)37-45
JournalCurrent Opinion in Pulmonary Medicine
Volume20
Issue number1
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy

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