Abstract
Kupffer cells and parenchymal cells of rat liver were isolated shortly after a single intravenous injection, or a constant infusion, of either thoracic duct lymph or isolated chylomicrons. The uptake of labeled free and esterified chylomicron cholesterol by the two cell types was compared to that of colloidal chromic [32P] phosphate. On the average, only about 6% of the cholesteryl ester of the chylomicrons taken up by liver was found m Kupffer cells. The chylomicron cholesteryl ester concentration (per mg N) in isolated parenchymal cells was equal to, or greater than, that of whole liver. The findings suggest that chylomicron remnants are removed from the circulation primarily by the parenchymal cells of the liver.
| Original language | English |
|---|---|
| Pages (from-to) | 137-142 |
| Number of pages | 6 |
| Journal | Biochimica et Biophysica Acta |
| Volume | 248 |
| Issue number | 1 |
| Publication status | Published - 1971 Oct 1 |
Subject classification (UKÄ)
- Cell and Molecular Biology