Distribution of pancreatic polypeptide and peptide YY.

Eva Ekblad, Frank Sundler

Research output: Contribution to journalArticlepeer-review

192 Citations (SciVal)


The cellular distribution of PP and PYY in mammals is reviewed. Expression of PP is restricted to endocrine cells mainly present in the pancreas predominantly in the duodenal portion (head) but also found in small numbers in the gastro-intestinal tract. PYY has a dual expression in both endocrine cells and neurons. PYY expressing endocrine cells occur all along the gastrointestinal tract and are frequent in the distal portion. Islet cells expressing PYY are found in many species. In rodents they predominate in the splenic portion (tail) of the pancreas. A limited expression of PYY is found also in endocrine cells in the adrenal gland, respiratory tract and pituitary. Peripheral, particularly enteric, neurons also express PYY as does a restricted set of central neurons.
Original languageEnglish
Pages (from-to)251-261
Issue number2
Publication statusPublished - 2002

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Diabetes, Metabolism and Endocrinology (LUR000004)

Subject classification (UKÄ)

  • Cell and Molecular Biology


  • Endocrine Glands/metabolism
  • Human
  • Microscopy
  • Fluorescence
  • Neurons/metabolism
  • Pancreas/*metabolism
  • Pancreatic Polypeptide/*biosynthesis
  • Peptide YY/*metabolism
  • Respiratory System/metabolism
  • Rats
  • Animal
  • Spleen/metabolism
  • Support
  • Non-U.S. Gov't
  • Adrenal Glands/metabolism


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