Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease — Learnings from brain imaging biomarkers

Kerstin Heurling, Edvin Johansson, Antoine Leuzy

Research output: Contribution to journalReview articlepeer-review

Abstract

Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer's disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.

Original languageEnglish
Pages (from-to)111-130
Number of pages20
JournalInternational Review of Neurobiology
Volume154
Early online date2020 Jul 11
DOIs
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Neurosciences

Free keywords

  • Brain metabolites
  • Fatty acids
  • Hyperglycemia
  • Magnetic resonance imaging
  • Medical imaging
  • Metabolism
  • Neuroimaging
  • Positron emission tomography
  • Spectroscopy

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