Diversity and functions of intestinal mononuclear phagocytes

T. Joeris, K. Müller-Luda, W. W. Agace, A. Mc I. Mowat

Research output: Contribution to journalReview articlepeer-review

Abstract

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for â €fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

Original languageEnglish
Pages (from-to)845-864
Number of pages20
JournalMucosal Immunology
Volume10
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

Subject classification (UKÄ)

  • Immunology in the medical area

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