DNA-cationic amphiphile interactions

Maria Miguel, Alberto A C C Pais, Rita Dias, Cecilia Leal, Monica Rosa, Björn Lindman

Research output: Contribution to journalArticlepeer-review

68 Citations (SciVal)


DNA shows strong interactions with cationic cosolutes and these have both biological and technological significance. We outline our research on various mixed system
of DNA and cationic amphiphiles including the interaction of DNA with simple cationic surfactants as well as the interaction with catanionic mixtures and positively charged catanionic vesicles. An overview from phase behavior to microstructure will be presented. We will also address DNA compaction and decompaction phenomena in different systems. Finally, simulations on DNA confinement and interaction with cationic polyions are considered. (C) 2003 Published by Elsevier B.V.
Original languageEnglish
Pages (from-to)43-55
JournalColloids and Surfaces a-Physicochemical and Engineering Aspects
Issue number1-3
Publication statusPublished - 2003

Subject classification (UKÄ)

  • Physical Chemistry


  • Fluorescence microscopy
  • DNA compaction/decompaction
  • DNA hydration
  • Phase behavior
  • Polyions
  • DNA–amphiphile complexes
  • Catanionic vesicles
  • Catanionic mixtures
  • Amino acid-based surfactants
  • DNA
  • Cationic amphiphiles/surfactants
  • Cryo-TEM
  • Small angle scattering
  • Sorption microcalorimetry
  • Molecular simulations


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