DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

Lena Nordström; Elin Andersson; Venera Kuci; Elin Gustavsson; Karolina Holm; Markus Ringnér; Per Guldberg; Sara Ek

doi:10.1186/s12885-015-1208-y

DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

Lena Nordström, Elin Andersson, Venera Kuci, Elin Gustavsson, Karolina Holm, Markus Ringnér, Per Guldberg, Sara Ek

Breastcancer-genetics

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Abstract

The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.

Original language	English
Article number	273
Journal	BMC Cancer
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12885-015-1208-y
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cancer and Oncology

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10.1186/s12885-015-1208-y

BMC_Nordstrom_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25880212?dopt=Abstract

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title = "DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.",

abstract = "The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.",

author = "Lena Nordstr{\"o}m and Elin Andersson and Venera Kuci and Elin Gustavsson and Karolina Holm and Markus Ringn{\'e}r and Per Guldberg and Sara Ek",

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doi = "10.1186/s12885-015-1208-y",

language = "English",

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journal = "BMC Cancer",

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T1 - DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

AU - Nordström, Lena

AU - Andersson, Elin

AU - Kuci, Venera

AU - Gustavsson, Elin

AU - Holm, Karolina

AU - Ringnér, Markus

AU - Guldberg, Per

AU - Ek, Sara

PY - 2015

Y1 - 2015

N2 - The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.

AB - The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.

UR - https://www.scopus.com/pages/publications/84928014401

U2 - 10.1186/s12885-015-1208-y

DO - 10.1186/s12885-015-1208-y

M3 - Article

C2 - 25880212

SN - 1471-2407

VL - 15

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 273

ER -

DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

Abstract

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