Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

Eva Netterlid, Monica Hindsén, Ingrid Siemund, Jonas Björk, Sonja Werner, Helene Jacobsson, Nuray Güner, Magnus Bruze

Research output: Contribution to journalArticlepeer-review

320 Downloads (Pure)


Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study of children and adults entering allergen-specific immunotherapy was performed using questionnaires and patch-testing. A total of 205 individuals completed the study. In the 3 study groups all subjects tested negative to aluminium before allergen-specific immunotherapy and 4 tested positive after therapy. In the control group 4 participants tested positive to aluminium. Six out of 8 who tested positive also had atopic dermatitis. Positive test results were found in 5/78 children and 3/127 adults. Allergen-specific immunotherapy was not shown to be a risk factor for contact allergy to aluminium. Among those who did develop aluminium allergy, children and those with atopic dermatitis were more highly represented.
Original languageEnglish
Pages (from-to)50-56
JournalActa Dermato-Venereologica
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases


Dive into the research topics of 'Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?'. Together they form a unique fingerprint.

Cite this