Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

P Piccini, D J Brooks, Anders Björklund, R N Gunn, P M Grasby, O Rimoldi, Patrik Brundin, Peter Hagell, Stig Rehncrona, Håkan Widner, Olle Lindvall

Research output: Contribution to journalArticlepeer-review

595 Citations (SciVal)

Abstract

Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.
Original languageEnglish
Pages (from-to)1137-1140
JournalNature Neuroscience
Volume2
Issue number12
DOIs
Publication statusPublished - 1999

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neurosurgery (013026000), Neurobiology (013212024), Older people’s health and Person-Centred care (013220012)

Subject classification (UKÄ)

  • Neurosciences

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