Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases

Fatima Costa, Emma Sparr, J. J. S. Sousa, A. A. C. C. Pais

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the cubic phases with higher viscosity. Studies on skin permeation showed that these latter formulations also presented lower permeability than the less viscous monoolein lamellar phases. Formulations containing cineol originated higher permeability with higher enhancement ratios. Thus, the various formulations are adapted to different circumstances and delivery routes. While a slow release is usually desired for drug sustained delivery, the transdermal route may require a faster release. Lamellar phases, which are less viscous, are more adapted to transdermal applications. Thus, systems involving lamellar phases of monoolein and cineol are good candidates to be used as skin permeation enhancers for propranolol hydrochloride.
Original languageEnglish
Title of host publicationColloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)
PublisherSpringer
Pages119-129
Volume135
ISBN (Print)978-3-540-85133-2
DOIs
Publication statusPublished - 2008
Event9th International Conference on Colloid Chemistry, 1997 - Siofok, Hungary
Duration: 1997 Jul 61997 Jul 12
Conference number: 9

Publication series

Name
Volume135
ISSN (Print)0340-255X

Conference

Conference9th International Conference on Colloid Chemistry, 1997
Country/TerritoryHungary
CitySiofok
Period1997/07/061997/07/12

Subject classification (UKÄ)

  • Physical Chemistry

Free keywords

  • Phytantriol
  • Monoolein
  • Lipid liquid crystalline phases
  • Drug release
  • Enhancers
  • Propranolol hydrochloride
  • Skin permeation

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