Drug release from lipid liquid crystalline phases: relation with phase behavior

Fatima Costa; Emma Sparr; Joao Jose Simoes Sousa; Alberto Canelas Pais

doi:10.3109/03639040903261997

Drug release from lipid liquid crystalline phases: relation with phase behavior

Fatima Costa, Emma Sparr, Joao Jose Simoes Sousa, Alberto Canelas Pais

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</.

Original language	English
Pages (from-to)	470-481
Journal	Drug Development and Industrial Pharmacy
Volume	36
Issue number	4
DOIs	https://doi.org/10.3109/03639040903261997
Publication status	Published - 2010

Subject classification (UKÄ)

Physical Chemistry

Free keywords

hydrochloride
propranolol
phytantriol
monoolein
drug release
Cubic phase
diolein

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10.3109/03639040903261997

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title = "Drug release from lipid liquid crystalline phases: relation with phase behavior",

abstract = "Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</.",

keywords = "hydrochloride, propranolol, phytantriol, monoolein, drug release, Cubic phase, diolein",

author = "Fatima Costa and Emma Sparr and {Simoes Sousa}, {Joao Jose} and Pais, {Alberto Canelas}",

year = "2010",

doi = "10.3109/03639040903261997",

language = "English",

volume = "36",

pages = "470--481",

journal = "Drug Development and Industrial Pharmacy",

issn = "0363-9045",

publisher = "Marcel Dekker",

number = "4",

}

TY - JOUR

T1 - Drug release from lipid liquid crystalline phases: relation with phase behavior

AU - Costa, Fatima

AU - Sparr, Emma

AU - Simoes Sousa, Joao Jose

AU - Pais, Alberto Canelas

PY - 2010

Y1 - 2010

N2 - Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</.

AB - Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</.

KW - hydrochloride

KW - propranolol

KW - phytantriol

KW - monoolein

KW - drug release

KW - Cubic phase

KW - diolein

U2 - 10.3109/03639040903261997

DO - 10.3109/03639040903261997

M3 - Article

SN - 0363-9045

VL - 36

SP - 470

EP - 481

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

IS - 4

ER -

Drug release from lipid liquid crystalline phases: relation with phase behavior

Abstract

Subject classification (UKÄ)

Free keywords

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