Drug transport in responding lipid membranes can be regulated by an external osmotic gradient

Fatima Costa, Christoffer Åberg, J J S Sousa, Emma Sparr

Research output: Contribution to journalArticlepeer-review

9 Citations (SciVal)

Abstract

In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.
Original languageEnglish
Pages (from-to)10307-10310
JournalLangmuir
Volume21
Issue number23
DOIs
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Physical Chemistry

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