Drugs affecting glycosaminoglycan metabolism

Giancarlo Ghiselli, Marco Maccarana

Research output: Contribution to journalReview articlepeer-review

Abstract

Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.

Original languageEnglish
Pages (from-to)1162-1169
Number of pages8
JournalDrug Discovery Today
Volume21
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Subject classification (UKÄ)

  • Cell and Molecular Biology

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