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Abstract
OBJECTIVE: In dynamic susceptibility contrast MRI (DSC-MRI), an arterial input function (AIF) is required to quantify perfusion. However, estimation of the concentration of contrast agent (CA) from magnitude MRI signal data is challenging. A reasonable alternative would be to quantify CA concentration using quantitative susceptibility mapping (QSM), as the CA alters the magnetic susceptibility in proportion to its concentration.
MATERIAL AND METHODS: AIFs with reasonable appearance, selected on the basis of conventional criteria related to timing, shape, and peak concentration, were registered from both ΔR2* and QSM images and mutually compared by visual inspection. Both ΔR2*- and QSM-based AIFs were used for perfusion calculations based on tissue concentration data from ΔR2*as well as QSM images.
RESULTS: AIFs based on ΔR2* and QSM data showed very similar shapes and the estimated cerebral blood flow values and mean transit times were similar. Analysis of corresponding ΔR2* versus QSM-based concentration estimates yielded a transverse relaxivity estimate of 89 s-1 mM-1, for voxels identified as useful AIF candidate in ΔR2* images according to the conventional criteria.
DISCUSSION: Interestingly, arterial concentration time curves based on ΔR2* versus QSM data, for a standard DSC-MRI experiment, were generally very similar in shape, and the relaxivity obtained in voxels representing blood was similar to tissue relaxivity obtained in previous studies.
Original language | English |
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Pages (from-to) | 663-676 |
Number of pages | 14 |
Journal | Magnetic Resonance Materials in Physics, Biology, and Medicine |
Volume | 33 |
Issue number | 5 |
Early online date | 2020 Feb 20 |
DOIs | |
Publication status | Published - 2020 Oct |
Subject classification (UKÄ)
- Radiology, Nuclear Medicine and Medical Imaging
- Other Physics Topics
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Optimisation and Validation of Dynamic Susceptibility Contrast MRI
Knutsson, L. (PI) & Wirestam, R. (PI)
1997/01/01 → …
Project: Research