Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

Linda Knutsson; Emelie Lind; André Ahlgren; Matthias J P van Osch; Karin Markenroth Bloch; Yulia Surova; Freddy Ståhlberg; Danielle van Westen; Ronnie Wirestam

doi:10.1002/mrm.25006

Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

Linda Knutsson, Emelie Lind, André Ahlgren, Matthias J P van Osch, Karin Markenroth Bloch, Yulia Surova, Freddy Ståhlberg, Danielle van Westen, Ronnie Wirestam

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Abstract

Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.

Original language	English
Pages (from-to)	996-1006
Journal	Magnetic Resonance in Medicine
Volume	72
Issue number	4
DOIs	https://doi.org/10.1002/mrm.25006
Publication status	Published - 2014

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging

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10.1002/mrm.25006

http://www.ncbi.nlm.nih.gov/pubmed/24285621?dopt=Abstract

16 Citations
1 Doctoral Thesis (compilation)

MRI Perfusion Measurements using Magnetic Susceptibility Effects: Calibration Approaches and Contrast Agent Quantification
Lind, E., 2019 Feb, Lund: Naturvetenskapliga fakulteten, Lunds universitet. 181 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
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1 Active

Optimisation and Validation of Dynamic Susceptibility Contrast MRI
Knutsson, L. & Wirestam, R.
1997/01/01 → …
Project: Research

Cite this

Knutsson, Linda ; Lind, Emelie ; Ahlgren, André ; van Osch, Matthias J P ; Markenroth Bloch, Karin ; Surova, Yulia ; Ståhlberg, Freddy ; van Westen, Danielle ; Wirestam, Ronnie. / Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion. In: Magnetic Resonance in Medicine. 2014 ; Vol. 72, No. 4. pp. 996-1006.

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title = "Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.",

abstract = "Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.",

author = "Linda Knutsson and Emelie Lind and Andr{\'e} Ahlgren and {van Osch}, {Matthias J P} and {Markenroth Bloch}, Karin and Yulia Surova and Freddy St{\aa}hlberg and {van Westen}, Danielle and Ronnie Wirestam",

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doi = "10.1002/mrm.25006",

language = "English",

volume = "72",

pages = "996--1006",

journal = "Magnetic Resonance in Medicine",

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Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion. / Knutsson, Linda ; Lind, Emelie; Ahlgren, André; van Osch, Matthias J P; Markenroth Bloch, Karin ; Surova, Yulia ; Ståhlberg, Freddy ; van Westen, Danielle ; Wirestam, Ronnie.

In: Magnetic Resonance in Medicine, Vol. 72, No. 4, 2014, p. 996-1006.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

AU - Knutsson, Linda

AU - Lind, Emelie

AU - Ahlgren, André

AU - van Osch, Matthias J P

AU - Markenroth Bloch, Karin

AU - Surova, Yulia

AU - Ståhlberg, Freddy

AU - van Westen, Danielle

AU - Wirestam, Ronnie

PY - 2014

Y1 - 2014

N2 - Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.

AB - Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.

U2 - 10.1002/mrm.25006

DO - 10.1002/mrm.25006

M3 - Article

C2 - 24285621

VL - 72

SP - 996

EP - 1006

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 1522-2594

IS - 4

ER -

Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

Abstract

Subject classification (UKÄ)

Access to Document

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Research output

MRI Perfusion Measurements using Magnetic Susceptibility Effects: Calibration Approaches and Contrast Agent Quantification

Projects

Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Cite this