Early probiotic supplementation and the risk of celiac disease in children at genetic risk

Ulla Uusitalo; Carin Andren Aronsson; Xiang Liu; Kalle Kurppa; Jimin Yang; Edwin Liu; Jennifer Skidmore; Christiane Winkler; Marian J. Rewers; William A. Hagopian; Jin Xiong She; Jorma Toppari; Anette G. Ziegler; Beena Akolkar; Jill M. Norris; Suvi M. Virtanen; Jeffrey P. Krischer; Daniel Agardh; TEDDY Study Group

doi:10.3390/nu11081790

Early probiotic supplementation and the risk of celiac disease in children at genetic risk

Ulla Uusitalo, Carin Andren Aronsson, Xiang Liu, Kalle Kurppa, Jimin Yang, Edwin Liu, Jennifer Skidmore, Christiane Winkler, Marian J. Rewers, William A. Hagopian, Jin Xiong She, Jorma Toppari, Anette G. Ziegler, Beena Akolkar, Jill M. Norris, Suvi M. Virtanen, Jeffrey P. Krischer, Daniel Agardh, TEDDY Study Group

Research output: Contribution to journal › Article › peer-review

Abstract

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

Original language	English
Article number	1790
Journal	Nutrients
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/nu11081790
Publication status	Published - 2019 Aug 1

Subject classification (UKÄ)

Pediatrics
Nutrition and Dietetics

Free keywords

Celiac disease
Celiac disease autoimmunity
Dietary supplements
Infant formula
Probiotics

Access to Document

10.3390/nu11081790Licence: CC BY

Cite this

Uusitalo, U., Aronsson, C. A., Liu, X., Kurppa, K., Yang, J., Liu, E., Skidmore, J., Winkler, C., Rewers, M. J., Hagopian, W. A., She, J. X., Toppari, J., Ziegler, A. G., Akolkar, B., Norris, J. M., Virtanen, S. M., Krischer, J. P., Agardh, D., & TEDDY Study Group (2019). Early probiotic supplementation and the risk of celiac disease in children at genetic risk. Nutrients, 11(8), Article 1790. https://doi.org/10.3390/nu11081790

@article{19690cd45a87451ba180452aa8a3c87a,

title = "Early probiotic supplementation and the risk of celiac disease in children at genetic risk",

abstract = "Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95\%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95\%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95\%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.",

keywords = "Celiac disease, Celiac disease autoimmunity, Dietary supplements, Infant formula, Probiotics",

author = "Ulla Uusitalo and Aronsson, \{Carin Andren\} and Xiang Liu and Kalle Kurppa and Jimin Yang and Edwin Liu and Jennifer Skidmore and Christiane Winkler and Rewers, \{Marian J.\} and Hagopian, \{William A.\} and She, \{Jin Xiong\} and Jorma Toppari and Ziegler, \{Anette G.\} and Beena Akolkar and Norris, \{Jill M.\} and Virtanen, \{Suvi M.\} and Krischer, \{Jeffrey P.\} and Daniel Agardh and \{TEDDY Study Group\}",

year = "2019",

month = aug,

day = "1",

doi = "10.3390/nu11081790",

language = "English",

volume = "11",

journal = "Nutrients",

issn = "2072-6643",

publisher = "MDPI AG",

number = "8",

}

Uusitalo, U, Aronsson, CA, Liu, X, Kurppa, K, Yang, J, Liu, E, Skidmore, J, Winkler, C, Rewers, MJ, Hagopian, WA, She, JX, Toppari, J, Ziegler, AG, Akolkar, B, Norris, JM, Virtanen, SM, Krischer, JP, Agardh, D & TEDDY Study Group 2019, 'Early probiotic supplementation and the risk of celiac disease in children at genetic risk', Nutrients, vol. 11, no. 8, 1790. https://doi.org/10.3390/nu11081790

TY - JOUR

T1 - Early probiotic supplementation and the risk of celiac disease in children at genetic risk

AU - Uusitalo, Ulla

AU - Aronsson, Carin Andren

AU - Liu, Xiang

AU - Kurppa, Kalle

AU - Yang, Jimin

AU - Liu, Edwin

AU - Skidmore, Jennifer

AU - Winkler, Christiane

AU - Rewers, Marian J.

AU - Hagopian, William A.

AU - She, Jin Xiong

AU - Toppari, Jorma

AU - Ziegler, Anette G.

AU - Akolkar, Beena

AU - Norris, Jill M.

AU - Virtanen, Suvi M.

AU - Krischer, Jeffrey P.

AU - Agardh, Daniel

AU - TEDDY Study Group

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

AB - Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

KW - Celiac disease

KW - Celiac disease autoimmunity

KW - Dietary supplements

KW - Infant formula

KW - Probiotics

UR - https://www.scopus.com/pages/publications/85070811472

U2 - 10.3390/nu11081790

DO - 10.3390/nu11081790

M3 - Article

C2 - 31382440

AN - SCOPUS:85070811472

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

IS - 8

M1 - 1790

ER -

Early probiotic supplementation and the risk of celiac disease in children at genetic risk

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

Other files and links

Fingerprint

Cite this