Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Roger Andersson; Maria Evertsson; Hanna Toftevall; Magnus Cinthio; Sarah Fredriksson; Tomas Jansson

doi:10.1109/ULTSYM.2016.7728380

Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Roger Andersson, Maria Evertsson, Hanna Toftevall, Magnus Cinthio, Sarah Fredriksson, Tomas Jansson

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

Original language	English
Title of host publication	2016 IEEE International Ultrasonics Symposium, IUS 2016
Publisher	IEEE Computer Society
Volume	2016-November
ISBN (Electronic)	9781467398978
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728380
Publication status	Published - 2016 Nov 1
Event	2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: 2016 Sept 18 → 2016 Sept 21

Conference

Conference	2016 IEEE International Ultrasonics Symposium, IUS 2016
Country/Territory	France
City	Tours
Period	2016/09/18 → 2016/09/21

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging

Free keywords

contrast agents
iron oxide
molecular imaging
nanoparticles
superparamagnetic

Access to Document

10.1109/ULTSYM.2016.7728380

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Andersson, R., Evertsson, M., Toftevall, H., Cinthio, M., Fredriksson, S., & Jansson, T. (2016). Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). Article 7728380 IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728380

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title = "Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging",

abstract = "Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.",

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author = "Roger Andersson and Maria Evertsson and Hanna Toftevall and Magnus Cinthio and Sarah Fredriksson and Tomas Jansson",

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doi = "10.1109/ULTSYM.2016.7728380",

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booktitle = "2016 IEEE International Ultrasonics Symposium, IUS 2016",

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Andersson, R, Evertsson, M, Toftevall, H, Cinthio, M, Fredriksson, S & Jansson, T 2016, Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728380, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 2016/09/18. https://doi.org/10.1109/ULTSYM.2016.7728380

Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging. / Andersson, Roger; Evertsson, Maria; Toftevall, Hanna et al.
2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728380.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

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T1 - Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

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AU - Evertsson, Maria

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AU - Cinthio, Magnus

AU - Fredriksson, Sarah

AU - Jansson, Tomas

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N2 - Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

AB - Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

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M3 - Paper in conference proceeding

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BT - 2016 IEEE International Ultrasonics Symposium, IUS 2016

PB - IEEE Computer Society

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Y2 - 18 September 2016 through 21 September 2016

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Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Abstract

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