Effectiveness and infectious complications of BCMA T-cell engagers in treating multiple myeloma: Real-world evidence from Sweden

Katarina Uttervall, Love Tätting, Konstantinos Lemonakis, Mousa Majd, Jacob Crafoord, Mikael Olsson, Ulf Henrik Mellqvist, Markus Hansson, Hareth Nahi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Multiple myeloma (MM), an incurable disease characterized by frequent relapses and a need for multiple treatments, often progresses to a relapse/refractory status resistant to all available drugs and drug classes. Bispecific antibodies, specifically BCMA T-cell engagers, have emerged as effective treatments for MM, demonstrating impressive efficacy. However, these treatments can adversely affect the immune system, increasing vulnerability to infections. Methods/Results: This study evaluated the efficacy and safety of BCMA T-cell engagers in 58 Swedish patients with poor MM prognosis. The patients exhibited a 69% overall response rate, with 69% survival and 60% progression-free survival at 15 months. Conclusions: Despite the risk of infectious complications, the prognosis of MM patients can be significantly improved with vigilant monitoring and proactive management of infections. This real-world data highlight the potential of BCMA T-cell engagers in treating MM, emphasizing the need for careful patient monitoring to mitigate infection risks.

Original languageEnglish
Article numbere7048
JournalCancer Medicine
Volume13
Issue number8
DOIs
Publication statusPublished - 2024 Apr

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • bispecific antibodies
  • immunotherapy
  • multiple myeloma
  • real-world data

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