Effects of CO2 anaesthesia on central nervous system activity in swine

L Martoft, L Lomholt, C Kolthoff, BE Rodriguez, EW Jensen, PF Jorgensen, HD Pedersen, Anders Forslid

Research output: Contribution to journalArticlepeer-review


The objective of the study was to examine the changes in central nervous system (CNS) activity and physical behaviour during induction and awakening from CO2 anaesthesia. Two studies, each using pigs immersed into 90% CO2 gas for a period of 60s were performed. In study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), electroencephalographic parameters (delta, theta, alpha and beta electroencephalographic power and 95% spectral edge frequency) and heart rate; and in study 2, we monitored body movements and arterial and venous partial pressure of CO2 and O-2. No behavioural signs of distress were observed during the early part of the induction. The swine exhibited muscular activity from 13-30s after induction-start as well as during awakening from anaesthesia, possibly because of a transitory weaker suppression of the brain stem than of the cortex. The CNS and blood gas parameters started to change from the very start of induction. The CNS suppression lasted only approximately one minute after the end of the induction period. The two studies indicated a good temporal relationship between changes in amplitude, depth of anaesthesia index, spectral edge frequency, and arterial P-CO2 during the induction period.
Original languageEnglish
Pages (from-to)115-126
JournalLaboratory Animals
Issue number2
Publication statusPublished - 2002

Subject classification (UKÄ)

  • Other Medical Sciences not elsewhere specified

Free keywords

  • carbon dioxide
  • depth
  • burst suppression
  • SEF
  • beta
  • alpha
  • theta
  • delta
  • EEG
  • auditory evoked potentials
  • CNS
  • P-CO2
  • P-O2 excitation
  • pig


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