Abstract
We investigated whether aminoguanidine (AG), an inhibitor of advanced glycated end product formation, or probucol (PB), a free radical scavenger, could influence signs of glomerular and distal tubular function and morphological changes in kidneys of male Wistar rats after 6 months of streptozocin (STZ)-induced diabetes. Diabetic rats had a higher kidney weight/body weight ratio (P<.001), but neither AG nor PB influenced the increased ratio. Diabetes caused an increased urinary albumin excretion (P<.05), which was normalized by AG, but further exaggerated by PB (P<.001). Diabetes also caused an increase in the urinary excretion of Tamm–Horsfall protein (P<.001). Both AG and PB attenuated this increase (P<.05 for both). A few glomeruli displayed focal thickening of varying degrees. Silver staining disclosed the glomerulopathy to be intercapillary glomerulosclerosis. Rats on PB-enriched diet displayed less pronounced changes than untreated rats (P<.01), while AG had no effect. The results suggest that oxidative stress could be involved in the development of diabetic nephropathy.
Original language | English |
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Pages (from-to) | 395-400 |
Journal | Journal of Diabetes and its Complications |
Volume | 16 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2002 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Medicine (Lund) (013230025), Ophthalmology (013242810), Pathology, (Lund) (013030000), Endocrinology (013241500)
Subject classification (UKÄ)
- Endocrinology and Diabetes
Free keywords
- Free Radical Scavengers: pharmacology
- Diabetic Nephropathies: physiopathology
- Disease Progression
- Experimental: physiopathology
- Probucol: pharmacology
- Rats
- Animal
- Diabetes Mellitus
- Non-U.S. Gov't
- Distal: physiopathology
- Male
- Oxidative Stress: physiology
- Support
- Wistar
- Kidney Tubules
- Distal: pathology
- Distal: drug effects
- Kidney Glomerulus: physiopathology
- Kidney Glomerulus: pathology
- Kidney Glomerulus: drug effects
- Guanidines: pharmacology
- Advanced: antagonists & inhibitors
- Glycosylation End Products
- Glycosylation