Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Elin Hall; Petr Volkov; Tasnim Dayeh; Karl Bacos; Tina Rönn; Marloes Dekker Nitert; Charlotte Ling

doi:10.1186/1741-7015-12-103

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Elin Hall, Petr Volkov, Tasnim Dayeh, Karl Bacos, Tina Rönn, Marloes Dekker Nitert, Charlotte Ling

Research output: Contribution to journal › Article › peer-review

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Abstract

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Original language	English
Article number	103
Journal	BMC Medicine
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1741-7015-12-103
Publication status	Published - 2014

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1741-7015-12-103

BMC__Hall_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24953961?dopt=Abstract

1 Doctoral Thesis (compilation)

Study of DNA methylation in human pancreatic islets
Hall, E., 2015, Epigenetics and Diabetes. 59 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

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title = "Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.",

abstract = "Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.",

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AU - Hall, Elin

AU - Volkov, Petr

AU - Dayeh, Tasnim

AU - Bacos, Karl

AU - Rönn, Tina

AU - Dekker Nitert, Marloes

AU - Ling, Charlotte

PY - 2014

Y1 - 2014

N2 - Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

AB - Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

U2 - 10.1186/1741-7015-12-103

DO - 10.1186/1741-7015-12-103

M3 - Article

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JO - BMC Medicine

JF - BMC Medicine

IS - 1

M1 - 103

ER -

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Study of DNA methylation in human pancreatic islets

Cite this