Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

C U Nilsson; P D Hellkvist; Martin Engström

doi:10.1111/j.1399-6576.2008.01735.x

Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

C U Nilsson, P D Hellkvist, Martin Engström

Anesthesiology and Intensive Care

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.

Original language	English
Pages (from-to)	1246-1249
Journal	Acta Anaesthesiologica Scandinavica
Volume	52
Issue number	9
DOIs	https://doi.org/10.1111/j.1399-6576.2008.01735.x
Publication status	Published - 2008

Subject classification (UKÄ)

Anesthesiology and Intensive Care

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10.1111/j.1399-6576.2008.01735.x

http://www.ncbi.nlm.nih.gov/pubmed/18823464?dopt=Abstract

Koagulation vid kirurgi och kritisk sjukdom
Schött, U. (PI)
1990/05/01 → 2019/03/31
Project: Research

Cite this

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title = "Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.",

abstract = "BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.",

author = "Nilsson, {C U} and Hellkvist, {P D} and Martin Engstr{\"o}m",

year = "2008",

doi = "10.1111/j.1399-6576.2008.01735.x",

language = "English",

volume = "52",

pages = "1246--1249",

journal = "Acta Anaesthesiologica Scandinavica",

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publisher = "Wiley-Blackwell",

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}

TY - JOUR

T1 - Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

AU - Nilsson, C U

AU - Hellkvist, P D

AU - Engström, Martin

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.

AB - BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.

U2 - 10.1111/j.1399-6576.2008.01735.x

DO - 10.1111/j.1399-6576.2008.01735.x

M3 - Article

SN - 0001-5172

VL - 52

SP - 1246

EP - 1249

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 9

ER -

Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

Abstract

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Koagulation vid kirurgi och kritisk sjukdom

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