Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain

Per Kjellstrand, Anders Edström, M Bjerkemo, Björn Holmquist

Research output: Contribution to journalArticlepeer-review

Abstract

Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.
Original languageEnglish
Pages (from-to)1-5
JournalToxicology Letters
Volume10
Issue number1
DOIs
Publication statusPublished - 1982

Subject classification (UKÄ)

  • Pharmacology and Toxicology

Free keywords

  • ACPase
  • acid phosphatase
  • ANOVA
  • analysis of variance
  • CNS
  • central nervous system
  • TCE
  • trichloroethylene

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