Abstract
Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.
Original language | English |
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Pages (from-to) | 1-5 |
Journal | Toxicology Letters |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1982 |
Subject classification (UKÄ)
- Pharmacology and Toxicology
Free keywords
- ACPase
- acid phosphatase
- ANOVA
- analysis of variance
- CNS
- central nervous system
- TCE
- trichloroethylene