Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Lucilene D. Mello, Emerson S. Ribeiro, Lauro T. Kubota, Sofi Elmroth, Regina M. S. Pereira

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)

Abstract

The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.
Original languageEnglish
Pages (from-to)385-392
JournalBioMetals
Volume22
Issue number2
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Biological Sciences

Keywords

  • Transition metal complexes
  • DNA
  • Platinum
  • DNA-metal complex interaction

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