Electrophysiological Assessment of Retinal Function During 6 Months of Bevacizumab Treatment in Neovascular Age-Related Macular Degeneration

Karen Bjerg Pedersen, Flemming Moller, Anne Katrin Sjolie, Sten Andréasson

Research output: Contribution to journalArticlepeer-review


Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in the central zone and after 3 and 6 months, improvement was seen in all 6 concentric rings corresponding to +/-25 degrees of the central visual field. Full-field electroretinography results indicated a decrease in cone photoreceptor function at 3 months, which was normalized at 6 months compared with baseline. Furthermore, 2 of 3 of the combined rod-cone responses showed signs of decreased retinal function at 6 months. Conclusion: Our results indicate passing signs of an altered retinal cone photoreceptor function assessed by full-field electroretinography. The results do not show any conclusive signs of global retinal toxicity after 6 months. Multifocal electroretinography results show improved photoreceptor function with no sign of focal toxicity in the central retina. RETINA 30:1025-1033, 2010
Original languageEnglish
Pages (from-to)1025-1033
Issue number7
Publication statusPublished - 2010

Subject classification (UKÄ)

  • Ophthalmology

Free keywords

  • full-field ERG
  • electrophysiology
  • CNV
  • bevacizumab
  • AMD
  • Avastin
  • multifocal ERG


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