Electrostatic Chameleons in Biological Systems.

Mikael Lund

doi:10.1021/ja106480a

Electrostatic Chameleons in Biological Systems.

Research output: Contribution to journal › Article › peer-review

Abstract

Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.

Original language	English
Pages (from-to)	17337-17339
Journal	Journal of the American Chemical Society
Volume	132
Issue number	49
DOIs	https://doi.org/10.1021/ja106480a
Publication status	Published - 2010

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)

Subject classification (UKÄ)

Theoretical Chemistry (including Computational Chemistry)

Access to Document

10.1021/ja106480a

Cite this

@article{a8897a0e2ce54c018f75f2ceeaa3de33,

title = "Electrostatic Chameleons in Biological Systems.",

abstract = "Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic {"}proximity switches{"} when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.",

author = "Mikael Lund",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)",

year = "2010",

doi = "10.1021/ja106480a",

language = "English",

volume = "132",

pages = "17337--17339",

journal = "Journal of the American Chemical Society",

issn = "1520-5126",

publisher = "The American Chemical Society (ACS)",

number = "49",

}

TY - JOUR

T1 - Electrostatic Chameleons in Biological Systems.

AU - Lund, Mikael

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)

PY - 2010

Y1 - 2010

N2 - Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.

AB - Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.

UR - https://www.scopus.com/pages/publications/78650135532

U2 - 10.1021/ja106480a

DO - 10.1021/ja106480a

M3 - Article

C2 - 21086991

SN - 1520-5126

VL - 132

SP - 17337

EP - 17339

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 49

ER -

Electrostatic Chameleons in Biological Systems.

Abstract

Bibliographical note

Subject classification (UKÄ)

Access to Document

Other files and links

Fingerprint

Cite this