Electrostatic interactions are important for the distribution of Gd(DTPA)2– in articular cartilage

Jenny Algotsson; Jan Forsman; Daniel Topgaard; Olle Söderman

doi:10.1002/mrm.25889

Electrostatic interactions are important for the distribution of Gd(DTPA)^2– in articular cartilage

Jenny Algotsson, Jan Forsman, Daniel Topgaard, Olle Söderman

Research output: Contribution to journal › Article › peer-review

Abstract

The delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) method can be used to assess the content of glycosaminoglycan in cartilage. In in vitro and model studies, the content of glycosaminoglycan is often expressed in terms of a fixed charge density (FCD). Values of the fixed charge density obtained using the dGEMRIC method differs from values obtained using other methods. The purpose of this work was to further clarify the origin of this discrepancy.

Original language	English
Pages (from-to)	500-509
Journal	Magnetic Resonance in Medicine
Volume	76
Issue number	2
Early online date	2015 Sept 1
DOIs	https://doi.org/10.1002/mrm.25889
Publication status	Published - 2016

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Physical Chemistry 1 (S) (011001006), Theoretical Chemistry (S) (011001039)

Subject classification (UKÄ)

Radiology and Medical Imaging

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10.1002/mrm.25889

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title = "Electrostatic interactions are important for the distribution of Gd(DTPA)2– in articular cartilage",

abstract = "The delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) method can be used to assess the content of glycosaminoglycan in cartilage. In in vitro and model studies, the content of glycosaminoglycan is often expressed in terms of a fixed charge density (FCD). Values of the fixed charge density obtained using the dGEMRIC method differs from values obtained using other methods. The purpose of this work was to further clarify the origin of this discrepancy.",

author = "Jenny Algotsson and Jan Forsman and Daniel Topgaard and Olle S{\"o}derman",

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AU - Forsman, Jan

AU - Topgaard, Daniel

AU - Söderman, Olle

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Physical Chemistry 1 (S) (011001006), Theoretical Chemistry (S) (011001039)

PY - 2016

Y1 - 2016

N2 - The delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) method can be used to assess the content of glycosaminoglycan in cartilage. In in vitro and model studies, the content of glycosaminoglycan is often expressed in terms of a fixed charge density (FCD). Values of the fixed charge density obtained using the dGEMRIC method differs from values obtained using other methods. The purpose of this work was to further clarify the origin of this discrepancy.

AB - The delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) method can be used to assess the content of glycosaminoglycan in cartilage. In in vitro and model studies, the content of glycosaminoglycan is often expressed in terms of a fixed charge density (FCD). Values of the fixed charge density obtained using the dGEMRIC method differs from values obtained using other methods. The purpose of this work was to further clarify the origin of this discrepancy.

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JF - Magnetic Resonance in Medicine

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ER -

Electrostatic interactions are important for the distribution of Gd(DTPA)^2– in articular cartilage

Abstract

Bibliographical note

Subject classification (UKÄ)

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Ions in models of articular cartilage: The importance of electrostatic interactions for transport and equilibrium distribution

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