Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

Ana Inacio; Yawei Liu; Bettina H Clausen; Martina Svensson; Krzysztof Kucharz; Yiyi Yang; Totte Stankovich; Reza Khorooshi; Kate L Lambertsen; Shohreh Issazadeh-Navikas; Tomas Deierborg

doi:10.1186/s12974-015-0427-0

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

Ana Inacio, Yawei Liu, Bettina H Clausen, Martina Svensson, Krzysztof Kucharz, Yiyi Yang, Totte Stankovich, Reza Khorooshi, Kate L Lambertsen, Shohreh Issazadeh-Navikas, Tomas Deierborg

Research output: Contribution to journal › Article › peer-review

Abstract

Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.

Original language	English
Article number	211
Journal	Journal of Neuroinflammation
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/s12974-015-0427-0
Publication status	Published - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuroinflammation (013210006), Faculty of Medicine (000022000), Laboratory for Experimental Brain Research (013041000)

Subject classification (UKÄ)

Neurosciences

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10.1186/s12974-015-0427-0

http://www.ncbi.nlm.nih.gov/pubmed/26581581?dopt=Abstract

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Inacio, A., Liu, Y., Clausen, B. H., Svensson, M., Kucharz, K., Yang, Y., Stankovich, T., Khorooshi, R., Lambertsen, K. L., Issazadeh-Navikas, S., & Deierborg, T. (2015). Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia. Journal of Neuroinflammation, 12(1), Article 211. https://doi.org/10.1186/s12974-015-0427-0

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title = "Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.",

abstract = "Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.",

author = "Ana Inacio and Yawei Liu and Clausen, {Bettina H} and Martina Svensson and Krzysztof Kucharz and Yiyi Yang and Totte Stankovich and Reza Khorooshi and Lambertsen, {Kate L} and Shohreh Issazadeh-Navikas and Tomas Deierborg",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroinflammation (013210006), Faculty of Medicine (000022000), Laboratory for Experimental Brain Research (013041000)",

year = "2015",

doi = "10.1186/s12974-015-0427-0",

language = "English",

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T1 - Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

AU - Inacio, Ana

AU - Liu, Yawei

AU - Clausen, Bettina H

AU - Svensson, Martina

AU - Kucharz, Krzysztof

AU - Yang, Yiyi

AU - Stankovich, Totte

AU - Khorooshi, Reza

AU - Lambertsen, Kate L

AU - Issazadeh-Navikas, Shohreh

AU - Deierborg, Tomas

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroinflammation (013210006), Faculty of Medicine (000022000), Laboratory for Experimental Brain Research (013041000)

PY - 2015

Y1 - 2015

N2 - Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.

AB - Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.

U2 - 10.1186/s12974-015-0427-0

DO - 10.1186/s12974-015-0427-0

M3 - Article

C2 - 26581581

SN - 1742-2094

VL - 12

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

IS - 1

M1 - 211

ER -

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

Abstract

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