Enteric neuropathy can be induced by high fat diet in vivo and palmitic Acid exposure in vitro.

Ulrikke Voss; Elin Sand; Björn Olde; Eva Ekblad

doi:10.1371/journal.pone.0081413

Enteric neuropathy can be induced by high fat diet in vivo and palmitic Acid exposure in vitro.

Ulrikke Voss, Elin Sand, Björn Olde, Eva Ekblad

Cardiology

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Abstract

Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model.

Original language	English
Article number	e81413
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0081413
Publication status	Published - 2013

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease
Gastroenterology and Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0081413

PLoS__Voss_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24312551?dopt=Abstract

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title = "Enteric neuropathy can be induced by high fat diet in vivo and palmitic Acid exposure in vitro.",

abstract = "Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model.",

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AU - Voss, Ulrikke

AU - Sand, Elin

AU - Olde, Björn

AU - Ekblad, Eva

PY - 2013

Y1 - 2013

N2 - Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model.

AB - Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model.

U2 - 10.1371/journal.pone.0081413

DO - 10.1371/journal.pone.0081413

M3 - Article

C2 - 24312551

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 12

M1 - e81413

ER -

Enteric neuropathy can be induced by high fat diet in vivo and palmitic Acid exposure in vitro.

Abstract

Subject classification (UKÄ)

UN SDGs

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