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Abstract
Perfluorinated compounds (PFCs), phthalates, manganese and selenium are ubiquitous in the environment and humans and influence fetal growth and development. Register and biobank based case-control studies were conducted to investigate the relationship between prenatal exposure to these chemicals and attention deficit hyperactivity disorder (ADHD) in childhood.
The study base comprised children born in Malmö, Sweden, between 1978 and 2000 that were followed up until 2005. Children with ADHD (n=206) were identified at the Department of Child and Adolescent Psychiatry in Malmö. Controls (n=206) were selected from the study base and were matched for year of birth and maternal country of origin.
Concentrations of PFCs, phthalates, manganese, and selenium were measured in umbilical cord serum samples collected from a maternity unit biobank in Malmö.
No associations between prenatal exposure to PFCs, phthalates, and manganese and ADHD in childhood were found. Selenium, which was hypothesized to protect against ADHD, was found to be positively associated with ADHD diagnosis in childhood. These findings need to be replicated in other larger studies before definitive conclusions can be drawn.
The study base comprised children born in Malmö, Sweden, between 1978 and 2000 that were followed up until 2005. Children with ADHD (n=206) were identified at the Department of Child and Adolescent Psychiatry in Malmö. Controls (n=206) were selected from the study base and were matched for year of birth and maternal country of origin.
Concentrations of PFCs, phthalates, manganese, and selenium were measured in umbilical cord serum samples collected from a maternity unit biobank in Malmö.
No associations between prenatal exposure to PFCs, phthalates, and manganese and ADHD in childhood were found. Selenium, which was hypothesized to protect against ADHD, was found to be positively associated with ADHD diagnosis in childhood. These findings need to be replicated in other larger studies before definitive conclusions can be drawn.
| Original language | English |
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| Qualification | Doctor |
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| Supervisors/Advisors |
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| Award date | 2015 May 8 |
| Publisher | |
| ISBN (Print) | 978-91-7619-121-7 |
| Publication status | Published - 2015 |
Bibliographical note
Defence detailsDate: 2015-05-08
Time: 09:00
Place: Segerfalksalen, BMC A10, Sölvegatan 17, Lund.
External reviewer(s)
Name: Bornehag, Carl-Gustaf
Title: Professor
Affiliation: Institutionen för hälsovetenskaper, Karlstads universitet
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Subject classification (UKÄ)
- Occupational Health and Environmental Health
Free keywords
- PFCs
- manganese
- selenium
- phthalates
- ADHD
- fetus
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Dive into the research topics of 'Environmental Toxins and Essential Trace Elements at Delivery and ADHD'. Together they form a unique fingerprint.Research output
- 3 Article
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Manganese and selenium concentrations in umbilical cord serum and attention deficit hyperactivity disorder in childhood.
Ode, A., Rylander, L., Gustafsson, P., Lundh, T., Källén, K., Olofsson, P., Ivarsson, S. & Rignell-Hydbom, A., 2015, In: Environmental Research. 137, p. 373-381Research output: Contribution to journal › Article › peer-review
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Fetal exposure to perfluorinated compounds and attention deficit hyperactivity disorder in childhood.
Ode, A., Källén, K., Gustafsson, P., Rylander, L., Jönsson, B. A., Olofsson, P., Ivarsson, S., Lindh, C. & Rignell-Hydbom, A., 2014, In: PLoS ONE. 9, 4, e95891.Research output: Contribution to journal › Article › peer-review
Open AccessFile189 Downloads (Pure) -
Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds.
Ode, A., Rylander, L., Lindh, C., Källén, K., Jönsson, B. A., Gustafsson, P., Olofsson, P., Ivarsson, S. & Rignell-Hydbom, A., 2013, In: Environmental Science and Pollution Research. 20, 11, p. 7970-7978Research output: Contribution to journal › Article › peer-review
File278 Downloads (Pure)