Epidemiological register studies on pain - etiology, treatment, and mental health

Fabian Larrosa Pardo

Epidemiological register studies on pain - etiology, treatment, and mental health

Research output: Thesis › Doctoral Thesis (compilation)

273 Downloads (Pure)

Abstract

Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the
pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the
wider society. Especially since pain can start early in life and affect large parts of it.
The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated
comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers
available in Sweden to perform four population-based cohort studies.
Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three
diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three
diseases were risk factors for widespread pain.
Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional
relationship where the two conditions increase the risk for each other.
Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous
opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the
risk.
Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated
prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a
steep increase in mental health conditions and associated prescription drugs.
Our results propose early identification and treatment for chronic diseases where recurrent pain is a common
symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each
other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing.
This is especially important since our studies also show that both pain and mental illness and associated prescription
drugs are common in young people. Finally, screening for previous regular opioid use could be considered when
initiating treatment for distal radius fracture.

Original language	English
Qualification	Doctor
Awarding Institution	Department of Clinical Sciences, Lund
Supervisors/Advisors	Jöud, Anna, Supervisor Petersson, Ingemar, Assistant supervisor Schelin, Maria, Assistant supervisor
Award date	2023 Sept 1
Place of Publication	Lund
Publisher	Lund University, Faculty of Medicine
ISBN (Print)	978-91-8021-434-6
Publication status	Published - 2023

Bibliographical note

Defence details
Date: 2023-09-01
Time: 09:00
Place: Belfragesalen, BMC D15, Klinikgatan 32 i Lund. Zoom: https://lu-se.zoom.us/j/62427077549
External reviewer(s)
Name: Mansfield, Kathryn
Title: Associate Professor
Affiliation: London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and population Health, Department of Non-Communicable Disease Epidemiology

Subject classification (UKÄ)

Public Health, Global Health, Social Medicine and Epidemiology

Free keywords

Pain
Epidemiology
register studies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

Fabian Larrosa Pardo - WEBBFinal published version, 3.34 MBLicence: CC BY-NC-ND

3 Article

Prolonged opioid use after distal radius fracture
Larrosa Pardo, F., Bondesson, E., Petersson, I. F., Schelin, M. E. C. & Jöud, A., 2023, In: European Journal of Pain. 27, 7, p. 848-859
Research output: Contribution to journal › Article › peer-review
A diagnosis of rheumatoid arthritis, endometriosis or IBD is associated with later onset of fibromyalgia and chronic widespread pain
Larrosa Pardo, F., Bondesson, E., Schelin, M. E. C. & Jöud, A., 2019, In: European Journal of Pain. 23, 8, p. 1563-1573
Research output: Contribution to journal › Article › peer-review
Comorbidity between pain and mental illness - Evidence of a bidirectional relationship
Bondesson, E., Larrosa Pardo, F., Stigmar, K., Ringqvist, A., Petersson, I. F., Jöud, A. & Schelin, M. E. C., 2018 Aug, In: European Journal of Pain. 22, 7, p. 1304-1311
Research output: Contribution to journal › Article › peer-review

Cite this

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title = "Epidemiological register studies on pain - etiology, treatment, and mental health",

abstract = "Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the wider society. Especially since pain can start early in life and affect large parts of it. The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers available in Sweden to perform four population-based cohort studies. Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three diseases were risk factors for widespread pain. Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional relationship where the two conditions increase the risk for each other. Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the risk. Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a steep increase in mental health conditions and associated prescription drugs. Our results propose early identification and treatment for chronic diseases where recurrent pain is a common symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing. This is especially important since our studies also show that both pain and mental illness and associated prescription drugs are common in young people. Finally, screening for previous regular opioid use could be considered when initiating treatment for distal radius fracture. ",

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note = "Defence details Date: 2023-09-01 Time: 09:00 Place: Belfragesalen, BMC D15, Klinikgatan 32 i Lund. Zoom: https://lu-se.zoom.us/j/62427077549 External reviewer(s) Name: Mansfield, Kathryn Title: Associate Professor Affiliation: London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and population Health, Department of Non-Communicable Disease Epidemiology",

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AU - Larrosa Pardo, Fabian

N1 - Defence details Date: 2023-09-01 Time: 09:00 Place: Belfragesalen, BMC D15, Klinikgatan 32 i Lund. Zoom: https://lu-se.zoom.us/j/62427077549 External reviewer(s) Name: Mansfield, Kathryn Title: Associate Professor Affiliation: London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and population Health, Department of Non-Communicable Disease Epidemiology

PY - 2023

Y1 - 2023

N2 - Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the wider society. Especially since pain can start early in life and affect large parts of it. The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers available in Sweden to perform four population-based cohort studies. Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three diseases were risk factors for widespread pain. Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional relationship where the two conditions increase the risk for each other. Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the risk. Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a steep increase in mental health conditions and associated prescription drugs. Our results propose early identification and treatment for chronic diseases where recurrent pain is a common symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing. This is especially important since our studies also show that both pain and mental illness and associated prescription drugs are common in young people. Finally, screening for previous regular opioid use could be considered when initiating treatment for distal radius fracture.

AB - Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the wider society. Especially since pain can start early in life and affect large parts of it. The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers available in Sweden to perform four population-based cohort studies. Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three diseases were risk factors for widespread pain. Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional relationship where the two conditions increase the risk for each other. Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the risk. Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a steep increase in mental health conditions and associated prescription drugs. Our results propose early identification and treatment for chronic diseases where recurrent pain is a common symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing. This is especially important since our studies also show that both pain and mental illness and associated prescription drugs are common in young people. Finally, screening for previous regular opioid use could be considered when initiating treatment for distal radius fracture.

KW - smärta

KW - Registerstudier

KW - Epidemiologi

KW - Pain

KW - Epidemiology

KW - register studies

M3 - Doctoral Thesis (compilation)

SN - 978-91-8021-434-6

T3 - Lund University, Faculty of Medicine Doctoral Dissertation Series

PB - Lund University, Faculty of Medicine

CY - Lund

ER -

Epidemiological register studies on pain - etiology, treatment, and mental health

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Research output

Prolonged opioid use after distal radius fracture

A diagnosis of rheumatoid arthritis, endometriosis or IBD is associated with later onset of fibromyalgia and chronic widespread pain

Comorbidity between pain and mental illness - Evidence of a bidirectional relationship

Cite this