Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

Mario Maioli; Emilyn Alejandro; Giancarlo Tonolo; Lisa K. Gilliam; Lynn Bekris; Christiane S. Hampe; Domenica A Obinu; Alberto Manconi; Loreta Puddu; Kristian Lynch K; Åke Lernmark

doi:10.1210/jc.2004-0864

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

Mario Maioli, Emilyn Alejandro, Giancarlo Tonolo, Lisa K. Gilliam, Lynn Bekris, Christiane S. Hampe, Domenica A Obinu, Alberto Manconi, Loreta Puddu, Kristian Lynch K, Åke Lernmark

University of Washington, Seattle

Research output: Contribution to journal › Article › peer-review

Abstract

The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or the additional presence of islet antigen 2 (IA-2) autoantibodies, better define T1DM phenotypes among T2DM patients. GAD65 and IA-2 autoantibodies were analyzed in 1436 Sardinian subjects classified with T2DM and in 384 nondiabetic patient controls. Autoantibody binding specificity to the N-terminal, middle (M), and C-terminal (C) portions of the GAD65 molecule was evaluated. Among the T2DM patients, 5.1% had GAD65 (P < 0.001) and 2.4% had IA-2 autoantibodies, compared with 1.3 and 1.6%, respectively, among the controls. GAD65Ab-positive T2DM patients with M+C (epitope-specific)

Original language	English
Pages (from-to)	5675-5682
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	89
Issue number	11
DOIs	https://doi.org/10.1210/jc.2004-0864
Publication status	Published - 2004
Externally published	Yes

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2004-0864

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Maioli, M., Alejandro, E., Tonolo, G., Gilliam, L. K., Bekris, L., Hampe, C. S., Obinu, D. A., Manconi, A., Puddu, L., Lynch K, K., & Lernmark, Å. (2004). Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes. Journal of Clinical Endocrinology and Metabolism, 89(11), 5675-5682. https://doi.org/10.1210/jc.2004-0864

@article{ede405c6e8004e4493adff32aed80b24,

title = "Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.",

abstract = "The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or the additional presence of islet antigen 2 (IA-2) autoantibodies, better define T1DM phenotypes among T2DM patients. GAD65 and IA-2 autoantibodies were analyzed in 1436 Sardinian subjects classified with T2DM and in 384 nondiabetic patient controls. Autoantibody binding specificity to the N-terminal, middle (M), and C-terminal (C) portions of the GAD65 molecule was evaluated. Among the T2DM patients, 5.1% had GAD65 (P < 0.001) and 2.4% had IA-2 autoantibodies, compared with 1.3 and 1.6%, respectively, among the controls. GAD65Ab-positive T2DM patients with M+C (epitope-specific)",

author = "Mario Maioli and Emilyn Alejandro and Giancarlo Tonolo and Gilliam, {Lisa K.} and Lynn Bekris and Hampe, {Christiane S.} and Obinu, {Domenica A} and Alberto Manconi and Loreta Puddu and {Lynch K}, Kristian and {\AA}ke Lernmark",

year = "2004",

doi = "10.1210/jc.2004-0864",

language = "English",

volume = "89",

pages = "5675--5682",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "1945-7197",

publisher = "Oxford University Press",

number = "11",

}

Maioli, M, Alejandro, E, Tonolo, G, Gilliam, LK, Bekris, L, Hampe, CS, Obinu, DA, Manconi, A, Puddu, L, Lynch K, K & Lernmark, Å 2004, 'Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.', Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 11, pp. 5675-5682. https://doi.org/10.1210/jc.2004-0864

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes. / Maioli, Mario; Alejandro, Emilyn; Tonolo, Giancarlo et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 11, 2004, p. 5675-5682.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

AU - Maioli, Mario

AU - Alejandro, Emilyn

AU - Tonolo, Giancarlo

AU - Gilliam, Lisa K.

AU - Bekris, Lynn

AU - Hampe, Christiane S.

AU - Obinu, Domenica A

AU - Manconi, Alberto

AU - Puddu, Loreta

AU - Lynch K, Kristian

AU - Lernmark, Åke

PY - 2004

Y1 - 2004

N2 - The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or the additional presence of islet antigen 2 (IA-2) autoantibodies, better define T1DM phenotypes among T2DM patients. GAD65 and IA-2 autoantibodies were analyzed in 1436 Sardinian subjects classified with T2DM and in 384 nondiabetic patient controls. Autoantibody binding specificity to the N-terminal, middle (M), and C-terminal (C) portions of the GAD65 molecule was evaluated. Among the T2DM patients, 5.1% had GAD65 (P < 0.001) and 2.4% had IA-2 autoantibodies, compared with 1.3 and 1.6%, respectively, among the controls. GAD65Ab-positive T2DM patients with M+C (epitope-specific)

AB - The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or the additional presence of islet antigen 2 (IA-2) autoantibodies, better define T1DM phenotypes among T2DM patients. GAD65 and IA-2 autoantibodies were analyzed in 1436 Sardinian subjects classified with T2DM and in 384 nondiabetic patient controls. Autoantibody binding specificity to the N-terminal, middle (M), and C-terminal (C) portions of the GAD65 molecule was evaluated. Among the T2DM patients, 5.1% had GAD65 (P < 0.001) and 2.4% had IA-2 autoantibodies, compared with 1.3 and 1.6%, respectively, among the controls. GAD65Ab-positive T2DM patients with M+C (epitope-specific)

U2 - 10.1210/jc.2004-0864

DO - 10.1210/jc.2004-0864

M3 - Article

SN - 1945-7197

VL - 89

SP - 5675

EP - 5682

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 11

ER -

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

Abstract

Subject classification (UKÄ)

UN SDGs

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