Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Gustaf Lindgren; Lars Ekblad; Johan Vallon-Christersson; Elisabeth Kjellén; Maria Gebre-Medhin; Johan Wennerberg

doi:10.1186/1471-2407-14-648

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin, Johan Wennerberg

Skåne University Hospital

Research output: Contribution to journal › Article › peer-review

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Abstract

Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

Original language	English
Article number	648
Journal	BMC Cancer
Volume	14
DOIs	https://doi.org/10.1186/1471-2407-14-648
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Subject classification (UKÄ)

Cancer and Oncology

Access to Document

10.1186/1471-2407-14-648

BMC__Lindgren_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25182342?dopt=Abstract

Cite this

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title = "Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.",

abstract = "Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.",

author = "Gustaf Lindgren and Lars Ekblad and Johan Vallon-Christersson and Elisabeth Kjell{\'e}n and Maria Gebre-Medhin and Johan Wennerberg",

year = "2014",

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language = "English",

volume = "14",

journal = "BMC Cancer",

issn = "1471-2407",

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TY - JOUR

T1 - Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

AU - Lindgren, Gustaf

AU - Ekblad, Lars

AU - Vallon-Christersson, Johan

AU - Kjellén, Elisabeth

AU - Gebre-Medhin, Maria

AU - Wennerberg, Johan

PY - 2014

Y1 - 2014

N2 - Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

AB - Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

UR - https://www.scopus.com/pages/publications/84907387754

U2 - 10.1186/1471-2407-14-648

DO - 10.1186/1471-2407-14-648

M3 - Article

SN - 1471-2407

VL - 14

JO - BMC Cancer

JF - BMC Cancer

M1 - 648

ER -

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Abstract

UN SDGs

Subject classification (UKÄ)

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Other files and links

Fingerprint

Experimental studies on head and neck carcinoma with special reference to tumour cell response to trauma

Local recurrences in head and neck cancer – etiology and prevention

Cite this

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Abstract

UN SDGs

Subject classification (UKÄ)

Access to Document

Other files and links

Fingerprint

Research output

Experimental studies on head and neck carcinoma with special reference to tumour cell response to trauma

Projects

Local recurrences in head and neck cancer – etiology and prevention

Cite this