TY - JOUR
T1 - Estimating cardiac mechanical efficiency in a porcine ex situ working heart model
AU - Pigot, Harry
AU - Steen, Stig
AU - Soltesz, Kristian
PY - 2024
Y1 - 2024
N2 - We introduce a method for assessing cardiac mechanical efficiency via a porcine ex situ biventricular working heart model, designed to closely replicate physiological conditions and improve the evaluation of donor heart viability for transplantation. The method aims to provide decision support for the safe utilization of hearts that might otherwise be discarded. Quantifying the heart’s pumping work against its chemical energy yield, our model advances traditional assessments by incorporating dynamic flow impedances to simulate real-world cardiac loads. We calculate mechanical efficiency by measuring aortic pressure, cardiac output, coronary flow, and blood-gas parameters in six porcine hearts beating in isolation, outside of the body, against computer-controlled dynamic flow impedances. The observed mean mechanical efficiency was 8.0±0.8 % (standard error of the mean), below the physiological norm of 25 %. This discrepancy underscores the influence of ex situ conditions on heart performance, as well as the limitations of standard estimation methods. Impacts of the ex situ setup as well as estimation improvements are discussed. Future research will explore integrating imaging technologies (MRI) to refine mechanical efficiency assessment.
AB - We introduce a method for assessing cardiac mechanical efficiency via a porcine ex situ biventricular working heart model, designed to closely replicate physiological conditions and improve the evaluation of donor heart viability for transplantation. The method aims to provide decision support for the safe utilization of hearts that might otherwise be discarded. Quantifying the heart’s pumping work against its chemical energy yield, our model advances traditional assessments by incorporating dynamic flow impedances to simulate real-world cardiac loads. We calculate mechanical efficiency by measuring aortic pressure, cardiac output, coronary flow, and blood-gas parameters in six porcine hearts beating in isolation, outside of the body, against computer-controlled dynamic flow impedances. The observed mean mechanical efficiency was 8.0±0.8 % (standard error of the mean), below the physiological norm of 25 %. This discrepancy underscores the influence of ex situ conditions on heart performance, as well as the limitations of standard estimation methods. Impacts of the ex situ setup as well as estimation improvements are discussed. Future research will explore integrating imaging technologies (MRI) to refine mechanical efficiency assessment.
KW - artificial organs and biomechanical systems;
KW - decision support systems
KW - cardiac mechanical efficiency
KW - biomedical system modelling
KW - ex situ working heart model
KW - functional heart assessment
U2 - 10.1016/j.ifacol.2024.11.011
DO - 10.1016/j.ifacol.2024.11.011
M3 - Article
SN - 2405-8963
SP - 55
EP - 60
JO - IFAC Proceedings Volumes (IFAC-PapersOnline)
JF - IFAC Proceedings Volumes (IFAC-PapersOnline)
T2 - 12th IFAC Symposium on Biological and Medical Systems (BMS)
Y2 - 11 September 2024 through 13 September 2024
ER -