Estimating the distribution of the G2 phase duration from flow cytometric histograms

Sara Larsson; Tobias Rydén; Ulla Holst; Stina Oredsson; Maria C Johansson

doi:10.1016/j.mbs.2007.08.009

Estimating the distribution of the G2 phase duration from flow cytometric histograms

Sara Larsson, Tobias Rydén, Ulla Holst, Stina Oredsson, Maria C Johansson

Research output: Contribution to journal › Article › peer-review

Abstract

A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

Original language	English
Pages (from-to)	1-17
Journal	Mathematical Biosciences
Volume	211
Issue number	1
DOIs	https://doi.org/10.1016/j.mbs.2007.08.009
Publication status	Published - 2008

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

Cell cycle progression
Branching process
G2 phase duration
Flow cytometry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mbs.2007.08.009

Cite this

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title = "Estimating the distribution of the G2 phase duration from flow cytometric histograms",

abstract = "A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.",

keywords = "Cell cycle progression, Branching process, G2 phase duration, Flow cytometry",

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AU - Larsson, Sara

AU - Rydén, Tobias

AU - Holst, Ulla

AU - Oredsson, Stina

AU - Johansson, Maria C

PY - 2008

Y1 - 2008

N2 - A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

AB - A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

KW - Cell cycle progression

KW - Branching process

KW - G2 phase duration

KW - Flow cytometry

U2 - 10.1016/j.mbs.2007.08.009

DO - 10.1016/j.mbs.2007.08.009

M3 - Article

SN - 0025-5564

VL - 211

SP - 1

EP - 17

JO - Mathematical Biosciences

JF - Mathematical Biosciences

IS - 1

ER -

Estimating the distribution of the G2 phase duration from flow cytometric histograms

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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Cite this