Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells

Wei-Qun Ding, Christer Larsson, Christer Alling

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the effect of ethanol exposure on the expression of fos and jun genes. Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. Four days of ethanol exposure also enhanced the AP-1 binding activity. Experiments with actinomycin D demonstrated that ethanol did not influence the degradation of c-jun and junD mRNAs. These results demonstrate that long-term exposure to ethanol increases c-jun and junD expression. This effect may be one of the mechanisms through which ethanol influences the gene regulatory system in neuronal cells.
Original languageEnglish
Pages (from-to)2191-2195
JournalNeuroReport
Volume7
Issue number13
Publication statusPublished - 1996

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Tumour Cell Biology (013017530)

Subject classification (UKÄ)

  • Neurosciences

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