Evaluation of a Fiber-Optic Based Pulsed Laser System for Fluorescence Spectroscopy

N Haj-Hosseini, Stefan Andersson-Engels, K Wardell

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

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Abstract

A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.
Original languageEnglish
Title of host publication14TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING AND MEDICAL PHYSICS
EditorsA Katashev, Y Dekhtyar, J Spigulis
Pages363-366
Volume20
DOIs
Publication statusPublished - 2008
Event14th Nordic-Baltic Conference an Biomedical Engineering and Medical Physics, Riga, LATVIA, JUN 16-20, 2008 -
Duration: 0001 Jan 2 → …

Publication series

Name
Volume20
ISSN (Print)1680-0737

Conference

Conference14th Nordic-Baltic Conference an Biomedical Engineering and Medical Physics, Riga, LATVIA, JUN 16-20, 2008
Period0001/01/02 → …

Subject classification (UKÄ)

  • Atom and Molecular Physics and Optics

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