Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.

Helena Grufman; Alexandru Schiopu; Andreas Edsfeldt; Harry Björkbacka; Mihaela Nitulescu; Marie MN Nilsson; Ana Persson; Jan Nilsson; Isabel Goncalves

doi:10.1016/j.atherosclerosis.2014.08.042

Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.

Helena Grufman, Alexandru Schiopu, Andreas Edsfeldt, Harry Björkbacka, Mihaela Nitulescu, Marie MN Nilsson, Ana Persson, Jan Nilsson, Isabel Goncalves

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Abstract

Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vulnerability is associated with increased plaque inflammation.

Original language	English
Pages (from-to)	177-182
Journal	Atherosclerosis
Volume	237
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2014.08.042
Publication status	Published - 2014

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

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10.1016/j.atherosclerosis.2014.08.042

Elsevier__Grufman_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25240113?dopt=Abstract

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title = "Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.",

abstract = "Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vulnerability is associated with increased plaque inflammation.",

author = "Helena Grufman and Alexandru Schiopu and Andreas Edsfeldt and Harry Bj{\"o}rkbacka and Mihaela Nitulescu and Nilsson, \{Marie MN\} and Ana Persson and Jan Nilsson and Isabel Goncalves",

year = "2014",

doi = "10.1016/j.atherosclerosis.2014.08.042",

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AU - Grufman, Helena

AU - Schiopu, Alexandru

AU - Edsfeldt, Andreas

AU - Björkbacka, Harry

AU - Nitulescu, Mihaela

AU - Nilsson, Marie MN

AU - Persson, Ana

AU - Nilsson, Jan

AU - Goncalves, Isabel

PY - 2014

Y1 - 2014

N2 - Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vulnerability is associated with increased plaque inflammation.

AB - Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vulnerability is associated with increased plaque inflammation.

UR - https://www.scopus.com/pages/publications/84907726913

U2 - 10.1016/j.atherosclerosis.2014.08.042

DO - 10.1016/j.atherosclerosis.2014.08.042

M3 - Article

C2 - 25240113

SN - 1879-1484

VL - 237

SP - 177

EP - 182

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.

Abstract

Subject classification (UKÄ)

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Inflammation, Plaque Vulnerability and Cardiovascular Risk

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