Evidence for Cardiomyocyte Renewal in Humans

Olaf Bergmann; Ratan D. Bhardwaj; Samuel Bernard; Sofia Zdunek; Fanie Barnabe-Heider; Stuart Walsh; Joel Zupicich; Kanar Alkass; Bruce A. Buchholz; Henrik Druid; Stefan Jovinge; Jonas Frisen

doi:10.1126/science.1164680

Evidence for Cardiomyocyte Renewal in Humans

Olaf Bergmann, Ratan D. Bhardwaj, Samuel Bernard, Sofia Zdunek, Fanie Barnabe-Heider, Stuart Walsh, Joel Zupicich, Kanar Alkass, Bruce A. Buchholz, Henrik Druid, Stefan Jovinge, Jonas Frisen

Stem Cell Center

Research output: Contribution to journal › Article › peer-review

Abstract

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

Original language	English
Pages (from-to)	98-102
Journal	Science
Volume	324
Issue number	5923
DOIs	https://doi.org/10.1126/science.1164680
Publication status	Published - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)

Subject classification (UKÄ)

Cell and Molecular Biology

Access to Document

10.1126/science.1164680

1 Doctoral Thesis (compilation)

Cardiomyocyte Cell Cycle, Renewal and Isolation
Walsh, S., 2010, Cardiovascular Laboratory, Center for Stem Cell Biology, Lund. 117 p.
Research output: Thesis › Doctoral Thesis (compilation)

File

Cite this

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title = "Evidence for Cardiomyocyte Renewal in Humans",

abstract = "It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.",

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doi = "10.1126/science.1164680",

language = "English",

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T1 - Evidence for Cardiomyocyte Renewal in Humans

AU - Bergmann, Olaf

AU - Bhardwaj, Ratan D.

AU - Bernard, Samuel

AU - Zdunek, Sofia

AU - Barnabe-Heider, Fanie

AU - Walsh, Stuart

AU - Zupicich, Joel

AU - Alkass, Kanar

AU - Buchholz, Bruce A.

AU - Druid, Henrik

AU - Jovinge, Stefan

AU - Frisen, Jonas

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)

PY - 2009

Y1 - 2009

N2 - It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

AB - It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

U2 - 10.1126/science.1164680

DO - 10.1126/science.1164680

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JO - Science

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ER -

Evidence for Cardiomyocyte Renewal in Humans

Abstract

Bibliographical note

Subject classification (UKÄ)

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Research output

Cardiomyocyte Cell Cycle, Renewal and Isolation

Cite this