Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

H A Hansson; L B Dahlin; Nils Danielsen; L Fryklund; A K Nachemson; P Polleryd; Bjorn Rozell; Anna Skottner; S Stemme; G Lundborg

doi:10.1111/j.1748-1716.1986.tb07862.x

Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

H A Hansson, L B Dahlin, Nils Danielsen, L Fryklund, A K Nachemson, P Polleryd, Bjorn Rozell, Anna Skottner, S Stemme, G Lundborg

Hand Surgery, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

Original language	English
Pages (from-to)	609-14
Number of pages	6
Journal	Acta Physiologica Scandinavica
Volume	126
Issue number	4
DOIs	https://doi.org/10.1111/j.1748-1716.1986.tb07862.x
Publication status	Published - 1986 Apr

Subject classification (UKÄ)

Neurosciences
Cell and Molecular Biology

Free keywords

Animals
Female
Fluorescent Antibody Technique
Insulin-Like Growth Factor I
Nerve Regeneration
Peripheral Nerves
Rats
Rats, Inbred Strains
Schwann Cells
Sciatic Nerve
Somatomedins
Time Factors
Journal Article
Research Support, Non-U.S. Gov't

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10.1111/j.1748-1716.1986.tb07862.x

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title = "Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves",

abstract = "The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.",

keywords = "Animals, Female, Fluorescent Antibody Technique, Insulin-Like Growth Factor I, Nerve Regeneration, Peripheral Nerves, Rats, Rats, Inbred Strains, Schwann Cells, Sciatic Nerve, Somatomedins, Time Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Hansson, \{H A\} and Dahlin, \{L B\} and Nils Danielsen and L Fryklund and Nachemson, \{A K\} and P Polleryd and Bjorn Rozell and Anna Skottner and S Stemme and G Lundborg",

year = "1986",

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doi = "10.1111/j.1748-1716.1986.tb07862.x",

language = "English",

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T1 - Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

AU - Hansson, H A

AU - Dahlin, L B

AU - Danielsen, Nils

AU - Fryklund, L

AU - Nachemson, A K

AU - Polleryd, P

AU - Rozell, Bjorn

AU - Skottner, Anna

AU - Stemme, S

AU - Lundborg, G

PY - 1986/4

Y1 - 1986/4

N2 - The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

AB - The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

KW - Animals

KW - Female

KW - Fluorescent Antibody Technique

KW - Insulin-Like Growth Factor I

KW - Nerve Regeneration

KW - Peripheral Nerves

KW - Rats

KW - Rats, Inbred Strains

KW - Schwann Cells

KW - Sciatic Nerve

KW - Somatomedins

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - https://www.scopus.com/pages/publications/0022452186

U2 - 10.1111/j.1748-1716.1986.tb07862.x

DO - 10.1111/j.1748-1716.1986.tb07862.x

M3 - Article

C2 - 3521205

SN - 0001-6772

VL - 126

SP - 609

EP - 614

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

IS - 4

ER -

Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

Abstract

Subject classification (UKÄ)

Free keywords

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