Abstract
Mammography population screening has been implemented based on evidence of efficacy from randomized controlled trials (RCTs). Substantial technical developments have witnessed an evolution from screen-film mammography (SFM) to full-field digital mammography (FFDM), and more recently to digital breast tomosynthesis as a potential screening modality. Mammography's technical evolution calls for consideration of the evidence required on the performance and effect of new screening technologies before these could be broadly recommended for screening. This chapter provides an overview of the technical background of the different mammography screening modalities, and an overview of the trials and studies that form the evidence-base for screening with FFDM and potentially for tomosynthesis. The transition to FFDM was underpinned by observational studies and an RCT showing (respectively) similar or higher cancer detection for FFDM compared to SFM. The evidence on screen-detection measures using tomosynthesis is emerging rapidly but there is limited data on whether this extends screening benefit.
| Original language | English |
|---|---|
| Title of host publication | Breast Cancer Screening: An Examination of Scientific Evidence |
| Publisher | Academic Press |
| Pages | 323-346 |
| Number of pages | 24 |
| ISBN (Print) | 9780128024942, 9780128022092 |
| DOIs | |
| Publication status | Published - 2016 |
Subject classification (UKÄ)
- Cancer and Oncology
Free keywords
- Breast cancer
- Breast tomosynthesis
- Digital mammography
- Interval cancer
- Overdiagnosis
- Population screening
- Screening performance
- Synthetic (reconstructed) mammogram
